IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0242244.html

Neurodevelopment of HIV-exposed uninfected children in Cape Town, South Africa

Author

Listed:
  • Hlengiwe P Madlala
  • Landon Myer
  • Thokozile R Malaba
  • Marie-Louise Newell

Abstract

Background: Evidence shows that antiretroviral (ART) exposure is associated with neurodevelopmental delays in human immunodeficiency virus (HIV)-exposed uninfected (HEU) children. However, there are few insights into modifiable maternal and child factors that may play a role in improving neurodevelopment in HEU children. We used a parent-centric neurodevelopment tool, Ages & Stages Questionnaire (ASQ) to examined neurodevelopment in HEU children at 12–24 months of age, and associations with maternal and child factors. Methods: 505 HIV-infected women (initiated ART pre- or during pregnancy) with live singleton births attending primary health care were enrolled; 355 of their HEU children were assessed for neurodevelopment (gross motor, fine motor, communication, problem solving and personal-social domains) at 12–24 months using age-specific ASQ administered by a trained fieldworker. Associations with maternal and child factors were examined using logistic regression models. Results: Among mothers (median age 30 years, IQR, 26–34), 52% initiated ART during pregnancy; the median CD4 count was 436 cells/μl (IQR, 305–604). Most delayed neurodevelopment in HEU children was in gross (9%) and fine motor (5%) functions. In adjusted models, maternal socio-economic status (aOR 0.42, 95% CI 0.24–0.76) was associated with reduced odds of delayed gross-fine motor neurodevelopment. Maternal age ≥35 years (aOR 0.22, 95% CI 0.05–0.89) and maternal body mass index (BMI)

Suggested Citation

  • Hlengiwe P Madlala & Landon Myer & Thokozile R Malaba & Marie-Louise Newell, 2020. "Neurodevelopment of HIV-exposed uninfected children in Cape Town, South Africa," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-20, November.
    • Handle: RePEc:plo:pone00:0242244
    DOI: 10.1371/journal.pone.0242244
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242244
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0242244&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0242244?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. repec:idb:brikps:publication-detail,7101.html?id=9402 is not listed on IDEAS
    2. Baker-Henningham, Helen & López Bóo, Florencia, 2010. "Early Childhood Stimulation Interventions in Developing Countries: A Comprehensive Literature Review," IZA Discussion Papers 5282, Institute for the Study of Labor (IZA).
    3. James J. Heckman & Dimitriy V. Masterov, 2007. "The Productivity Argument for Investing in Young Children," Review of Agricultural Economics, Agricultural and Applied Economics Association, vol. 29(3), pages 446-493.
    4. Myer, Landon & Stein, Dan J. & Grimsrud, Anna & Seedat, Soraya & Williams, David R., 2008. "Social determinants of psychological distress in a nationally-representative sample of South African adults," Social Science & Medicine, Elsevier, vol. 66(8), pages 1828-1840, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kasim Allel & Gerard Abou Jaoude & Stavros Poupakis & Neha Batura & Jolene Skordis & Hassan Haghparast-Bidgoli, 2021. "Exploring the Associations between Early Childhood Development Outcomes and Ecological Country-Level Factors across Low- and Middle-Income Countries," IJERPH, MDPI, vol. 18(7), pages 1-15, March.
    2. El-Kogali,Safaa El Tayeb & Krafft,Caroline Gould & Abdelkhalek,Touhami & Benkassmi,Mohamed & Chavez,Monica I. & Bassett,Lucy Katherine & Ejjanoui,Fouzia & El-Kogali,Safaa El Tayeb & Krafft,Caroline Go, 2016. "Inequality of opportunity in early childhood development in Morocco over time," Policy Research Working Paper Series 7670, The World Bank.
    3. Michael Marmot & Ruth Bell & Angela Donkin, 2013. "Tackling Structural and Social Issues to Reduce Inequities in Children’s Outcomes in Low- to Middle-income Countries," Papers indipa708, Innocenti Discussion Papers.
    4. DeMalach, Elad & Schlosser, Analia, 2024. "Short- and Long-Term Effects of Universal Preschool: Evidence from the Arab Population in Israel," CEPR Discussion Papers 18781, C.E.P.R. Discussion Papers.
    5. Sem J. Duijndam & W. J. Wouter Botzen & Liselotte C. Hagedoorn & Philip Bubeck & Toon Haer & My Pham & Jeroen C. J. H. Aerts, 2023. "Drivers of migration intentions in coastal Vietnam under increased flood risk from sea level rise," Climatic Change, Springer, vol. 176(2), pages 1-22, February.
    6. Cheng, Zhiming & Smyth, Russell & Zhang, Le, 2024. "Does childhood adversity affect household portfolio decisions? Evidence from the Chinese Great Famine," China Economic Review, Elsevier, vol. 87(C).
    7. Maclean, Johanna Catherine & Popovici, Ioana & French, Michael T., 2016. "Are natural disasters in early childhood associated with mental health and substance use disorders as an adult?," Social Science & Medicine, Elsevier, vol. 151(C), pages 78-91.
    8. Apps, Patricia & Mendolia, Silvia & Walker, Ian, 2013. "The impact of pre-school on adolescents’ outcomes: Evidence from a recent English cohort," Economics of Education Review, Elsevier, vol. 37(C), pages 183-199.
    9. Takuya Obara & Yoshitomo Ogawa, 2024. "Optimal taxation in an endogenous fertility model with non-cooperative behavior," Review of Economics of the Household, Springer, vol. 22(1), pages 173-197, March.
    10. Fujii, Tomoki & Shonchoy, Abu S. & Xu, Sijia, 2018. "Impact of Electrification on Children’s Nutritional Status in Rural Bangladesh," World Development, Elsevier, vol. 102(C), pages 315-330.
    11. Lauber, Verena & Thomas, Lampert, 2014. "The Effect of Early Universal Daycare on Child Weight Problems," VfS Annual Conference 2014 (Hamburg): Evidence-based Economic Policy 100399, Verein für Socialpolitik / German Economic Association.
    12. World Bank, 2017. "Pre-Primary Education in Mongolia," World Bank Publications - Reports 26402, The World Bank Group.
    13. Dena Ringold & Bénédicte de la Brière & Dominic Rohner & Deon Filmer & Karelle Samuda & Anastasiya Denisova, 2017. "From Mines and Wells to Well-Built Minds," World Bank Publications - Books, The World Bank Group, number 26490, April.
    14. Nabanita Datta Gupta & Marianne Simonsen, 2010. "Effects of Universal Child Care Participation on Pre-teen Skills and Risky Behaviors," Economics Working Papers 2010-07, Department of Economics and Business Economics, Aarhus University.
    15. Shelly Lundberg, 2013. "The College Type: Personality and Educational Inequality," Journal of Labor Economics, University of Chicago Press, vol. 31(3), pages 421-441.
    16. Nemeczek, Fabian & Radermacher, Jan, 2022. "Personality-augmented MPC: Linking survey and transaction data to explain MPC heterogeneity by Big Five personality traits," SAFE Working Paper Series 348, Leibniz Institute for Financial Research SAFE.
    17. Deniz Karaoğlan & Dürdane Şirin Saraçoğlu, 2018. "Socio-Economic Factors Affecting Early Childhood Health: the Case of Turkey," Child Indicators Research, Springer;The International Society of Child Indicators (ISCI), vol. 11(3), pages 1051-1075, June.
    18. World Bank, 2013. "Expanding and Improving Early Childhood Education in Turkey," World Bank Publications - Reports 16066, The World Bank Group.
    19. Francesco Agostinelli & Morteza Saharkhiz & Matthew Wiswall, 2019. "Home and School in the Development of Children," Working Papers 2019-044, Human Capital and Economic Opportunity Working Group.
    20. Laura Rossouw, 2015. "Poor Health Reporting: Do Poor South Africans Underestimate Their Health Needs?," WIDER Working Paper Series wp-2015-027, World Institute for Development Economic Research (UNU-WIDER).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0242244. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.