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Efficacy and Acceptability of Glycemic Control of Glucagon-Like Peptide-1 Receptor Agonists among Type 2 Diabetes: A Systematic Review and Network Meta-Analysis

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  • Zhixia Li
  • Yuan Zhang
  • Xiaochi Quan
  • Zhirong Yang
  • Xiantao Zeng
  • Linong Ji
  • Feng Sun
  • Siyan Zhan

Abstract

Objective: To synthesize current evidence of the impact of Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on hypoglycemia, treatment discontinuation and glycemic level in patients with type 2 diabetes. Design: Systematic review and network meta-analysis. Data Sources: Literature search (Medline, Embase, the Cochrane library), website of clinical trial, bibliographies of published systematic reviews. Eligibility Criteria: Randomized controlled trials with available data comparing GLP-1 RAs with placebo or traditional anti-diabetic drugs in patients with type 2 diabetes. Data Synthesis: Traditional pairwise meta-analyses within DerSimonian-Laird random effects model and network meta-analysis within a Bayesian framework were performed to calculate odds ratios for the incidence of hypoglycemia, treatment discontinuation, HbA1c

Suggested Citation

  • Zhixia Li & Yuan Zhang & Xiaochi Quan & Zhirong Yang & Xiantao Zeng & Linong Ji & Feng Sun & Siyan Zhan, 2016. "Efficacy and Acceptability of Glycemic Control of Glucagon-Like Peptide-1 Receptor Agonists among Type 2 Diabetes: A Systematic Review and Network Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-25, May.
    • Handle: RePEc:plo:pone00:0154206
    DOI: 10.1371/journal.pone.0154206
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    References listed on IDEAS

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