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Volunteer Bias in Recruitment, Retention, and Blood Sample Donation in a Randomised Controlled Trial Involving Mothers and Their Children at Six Months and Two Years: A Longitudinal Analysis

Author

Listed:
  • Sue Jordan
  • Alan Watkins
  • Mel Storey
  • Steven J Allen
  • Caroline J Brooks
  • Iveta Garaiova
  • Martin L Heaven
  • Ruth Jones
  • Sue F Plummer
  • Ian T Russell
  • Catherine A Thornton
  • Gareth Morgan

Abstract

Background: The vulnerability of clinical trials to volunteer bias is under-reported. Volunteer bias is systematic error due to differences between those who choose to participate in studies and those who do not. Methods and Results: This paper extends the applications of the concept of volunteer bias by using data from a trial of probiotic supplementation for childhood atopy in healthy dyads to explore 1) differences between a) trial participants and aggregated data from publicly available databases b) participants and non-participants as the trial progressed 2) impact on trial findings of weighting data according to deprivation (Townsend) fifths in the sample and target populations. 1) a) Recruits (n = 454) were less deprived than the target population, matched for area of residence and delivery dates (n = 6,893) (mean [SD] deprivation scores 0.09[4.21] and 0.79[4.08], t = 3.44, df = 511, p

Suggested Citation

  • Sue Jordan & Alan Watkins & Mel Storey & Steven J Allen & Caroline J Brooks & Iveta Garaiova & Martin L Heaven & Ruth Jones & Sue F Plummer & Ian T Russell & Catherine A Thornton & Gareth Morgan, 2013. "Volunteer Bias in Recruitment, Retention, and Blood Sample Donation in a Randomised Controlled Trial Involving Mothers and Their Children at Six Months and Two Years: A Longitudinal Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-16, July.
    • Handle: RePEc:plo:pone00:0067912
    DOI: 10.1371/journal.pone.0067912
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    References listed on IDEAS

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    1. Carol Propper & John Rigg & Simon Burgess, 2007. "Child health: evidence on the roles of family income and maternal mental health from a UK birth cohort," Health Economics, John Wiley & Sons, Ltd., vol. 16(11), pages 1245-1269.
    2. Carol Propper & John Rigg & Simon Burgess, 2007. "Child health: evidence on the roles of family income and maternal mental health from a UK birth cohort," Health Economics, John Wiley & Sons, Ltd., vol. 16(11), pages 1245-1269, November.
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