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Interactions between polygenic scores and environments: Methodological and conceptual challenges

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  • Domingue, Benjamin
  • Trejo, Sam
  • Armstrong-Carter, Emma
  • Tucker-Drob, Elliot M.

    (University of Texas at Austin)

Abstract

Interest in the study of gene-environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running cohort studies. Identifying and estimating statistical interactions comes with several analytic and inferential challenges; these challenges are heightened when used to integrate observational genomic and social science data. We articulate some of these key challenges, provide new perspectives on the study of gene-environment interactions, and finally offer some practical guidance for conducting research in this area. Given the sudden availability of well-powered polygenic scores, we anticipate a substantial increase in research testing for interaction between such scores and environments. The issues we discuss, if not properly addressed, may impact the enduring scientific value of gene-environment interaction studies.

Suggested Citation

  • Domingue, Benjamin & Trejo, Sam & Armstrong-Carter, Emma & Tucker-Drob, Elliot M., 2020. "Interactions between polygenic scores and environments: Methodological and conceptual challenges," SocArXiv u7sh4, Center for Open Science.
    • Handle: RePEc:osf:socarx:u7sh4
    DOI: 10.31219/osf.io/u7sh4
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    References listed on IDEAS

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    1. Boardman, J.D. & Daw, J. & Freese, J., 2013. "Defining the environment in gene-environment research: Lessons from social epidemiology," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 64-72.
    2. Silvia H. Barcellos & Leandro S. Carvalho & Patrick Turley, 2018. "Education can reduce health differences related to genetic risk of obesity," Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, vol. 115(42), pages 9765-9772, October.
    3. Thomas A. DiPrete & Casper A. P. Burik & Philipp D. Koellinger, 2018. "Genetic instrumental variable regression: Explaining socioeconomic and health outcomes in nonexperimental data," Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, vol. 115(22), pages 4970-4979, May.
    4. Chabris, C. F. & Lee, J. J. & Cesarini, D. & Benjamin, D. J. & Laibson, David I., 2015. "The Fourth Law of Behavior Genetics," Scholarly Articles 30780203, Harvard University Department of Economics.
    5. Felix C. Tropf & S. Hong Lee & Renske M. Verweij & Gert Stulp & Peter J. van der Most & Ronald de Vlaming & Andrew Bakshi & Daniel A. Briley & Charles Rahal & Robert Hellpap & Anastasia N. Iliadou & T, 2017. "Hidden heritability due to heterogeneity across seven populations," Nature Human Behaviour, Nature, vol. 1(10), pages 757-765, October.
    6. Barr, Peter B. & Silberg, Judy & Dick, Danielle M. & Maes, Hermine H., 2018. "Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk," Social Science & Medicine, Elsevier, vol. 209(C), pages 51-58.
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    Cited by:

    1. Baker, Samuel & Biroli, Pietro & van Kippersluis, Hans & von Hinke, Stephanie, 2022. "Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age," IZA Discussion Papers 15291, Institute of Labor Economics (IZA).
    2. Pietro Biroli & Titus Galama & Stephanie von Hinke & Hans van Kippersluis & Kevin Thom, 2022. "Economics and Econometrics of Gene-Environment Interplay," Bristol Economics Discussion Papers 22/759, School of Economics, University of Bristol, UK.
    3. Pereira, Rita & Biroli, Pietro & von hinke, stephanie & Van Kippersluis, Hans & Galama, Titus & Rietveld, Niels & Thom, Kevin, 2022. "Gene-Environment Interplay in the Social Sciences," OSF Preprints d96z3, Center for Open Science.
    4. Trejo, Sam, 2020. "Exploring Genetic Influences on Birth Weight," SocArXiv 7j59q, Center for Open Science.
    5. Das, Aniruddha, 2021. "The relational genomics of cognitive function: A longitudinal study," Social Science & Medicine, Elsevier, vol. 270(C).

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