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Closing the innovative loop: moving from the laboratory to the shop floor in biotechnology manufacturing

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  • Maryann P. Feldman
  • Cynthia R. Ronzio

Abstract

Innovation is a hallmark of successful technology-intensive start-up companies. This paper considers manufacturing as a knowledge-generating activity integral to product innovation in entrepreneurial biotechnology firms. The model of the virtual corporation has been advocated as a means to focus on the resources of start-up companies; yet regional specialization in technical applications and product categories suggests that manufacturing may be a knowledge-generating activity that can provide a potential source of regional advantage. This paper considers the manufacturing strategies that bio-entrepreneurs would like to pursue and explores barriers to forward integration. While capital constraints may force firms to licence and subcontract manufacturing, it was found that entrepreneurs believe that it is important to undertake manufacturing and, when they are financially able, they invest in manufacturing facilities. The authors conclude by providing a framework for considering when it might be most appropriate for biotechnology firms to invest in manufacturing.

Suggested Citation

  • Maryann P. Feldman & Cynthia R. Ronzio, 2001. "Closing the innovative loop: moving from the laboratory to the shop floor in biotechnology manufacturing," Entrepreneurship & Regional Development, Taylor & Francis Journals, vol. 13(1), pages 1-16, January.
    • Handle: RePEc:taf:entreg:v:13:y:2001:i:1:p:1-16
    DOI: 10.1080/08985620010005484
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    References listed on IDEAS

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    1. George W. Fenn & J. Nellie Liang & Stephen D. Prowse, 1995. "The economics of the private equity market," Staff Studies 168, Board of Governors of the Federal Reserve System (U.S.).
    2. Claude Barfield, 1997. "Science for the Twenty-First Century: The Bush Report Revisited," Books, American Enterprise Institute, number 53112, September.
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    Citations

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    Cited by:

    1. Pier Paolo Patrucco, 2005. "The emergence of technology systems: knowledge production and distribution in the case of the Emilian plastics district," Cambridge Journal of Economics, Cambridge Political Economy Society, vol. 29(1), pages 37-56, January.
    2. Robinson, Douglas K.R. & Rip, Arie & Mangematin, Vincent, 2007. "Technological agglomeration and the emergence of clusters and networks in nanotechnology," Research Policy, Elsevier, vol. 36(6), pages 871-879, July.
    3. Mark Lorenzen & Bo Carlsson, 2014. "Maryann Feldman: Recipient of the 2013 Global Award for Entrepreneurship Research," Small Business Economics, Springer, vol. 43(1), pages 1-8, June.
    4. Joseph Leibovitz, 2004. "'Embryonic' Knowledge-based Clusters and Cities: The Case of Biotechnology in Scotland," Urban Studies, Urban Studies Journal Limited, vol. 41(5-6), pages 1133-1155, May.
    5. Douglas K. R. Robinson & Arie Rip & Vincent Mangematin, 2007. "Technological agglomeration and the emergence of clusters and networks in nanotechnology," Post-Print hal-00424519, HAL.
    6. Sharmistha Bagchi-Sen & Helen Lawton Smith & Linda Hall, 2004. "The US Biotechnology Industry: Industry Dynamics and Policy," Environment and Planning C, , vol. 22(2), pages 199-216, April.
    7. Kasch, Silja & Dowling, Michael, 2008. "Commercialization strategies of young biotechnology firms: An empirical analysis of the U.S. industry," Research Policy, Elsevier, vol. 37(10), pages 1765-1777, December.
    8. Sharmistha Bagchi-Sen, 2006. "Strategic Considerations for Innovation and Commercialization in the US Biotechnology Sector," European Planning Studies, Taylor & Francis Journals, vol. 15(6), pages 753-766, May.
    9. Avenel, E. & Corolleur, F. & Gauthier, C. & Rieu, C., 2005. "Start-ups, firm growth and the consolidation of the French biotech industry," Working Papers 200503, Grenoble Applied Economics Laboratory (GAEL).
    10. Hullova, Dusana & Trott, Paul & Simms, Christopher Don, 2016. "Uncovering the reciprocal complementarity between product and process innovation," Research Policy, Elsevier, vol. 45(5), pages 929-940.
    11. Patrucco, Pier Paolo, 2004. "The Production of Collective Knowledge: Some Evidence from European Metropolitan Areas," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 200401, University of Turin.

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