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Economic evaluation of meningococcal vaccines: considerations for the future

Author

Listed:
  • Hannah Christensen

    (University of Bristol)

  • Hareth Al-Janabi

    (University of Birmingham)

  • Pierre Levy

    (Université Paris-Dauphine, PSL Research University, LEDa [LEGOS])

  • Maarten J. Postma

    (University Medical Center/University of Groningen
    University Medical Center/University of Groningen
    University Medical Center/University of Groningen)

  • David E. Bloom

    (Harvard University)

  • Paolo Landa

    (University of Exeter)

  • Oliver Damm

    (Bielefeld University)

  • David M. Salisbury

    (Centre on Global Health Security, Royal Institute of International Affairs)

  • Javier Diez-Domingo

    (FISABIO-Public Health)

  • Adrian K. Towse

    (Office of Health Economics)

  • Paula K. Lorgelly

    (Office of Health Economics)

  • Koonal K. Shah

    (Office of Health Economics)

  • Karla Hernandez-Villafuerte

    (Office of Health Economics
    German Cancer Research Center (DKFZ))

  • Vinny Smith

    (Meningitis Research Foundation)

  • Linda Glennie

    (Meningitis Research Foundation)

  • Claire Wright

    (Meningitis Research Foundation)

  • Laura York

    (Vaccine Medical Development, Scientific and Clinical Affairs, Pfizer Inc)

  • Raymond Farkouh

    (Pfizer Inc)

Abstract

In 2018, a panel of health economics and meningococcal disease experts convened to review methodologies, frameworks, and decision-making processes for economic evaluations of vaccines, with a focus on evaluation of vaccines targeting invasive meningococcal disease (IMD). The panel discussed vaccine evaluation methods across countries; IMD prevention benefits that are well quantified using current methods, not well quantified, or missing in current cost-effectiveness methodologies; and development of recommendations for future evaluation methods. Consensus was reached on a number of points and further consideration was deemed necessary for some topics. Experts agreed that the unpredictability of IMD complicates an accurate evaluation of meningococcal vaccine benefits and that vaccine cost-effectiveness evaluations should encompass indirect benefits, both for meningococcal vaccines and vaccines in general. In addition, the panel agreed that transparency in the vaccine decision-making process is beneficial and should be implemented when possible. Further discussion is required to ascertain: how enhancing consistency of frameworks for evaluating outcomes of vaccine introduction can be improved; reviews of existing tools used to capture quality of life; how indirect costs are considered within models; and whether and how the weighting of quality-adjusted life-years (QALY), application of QALY adjustment factors, or use of altered cost-effectiveness thresholds should be used in the economic evaluation of vaccines.

Suggested Citation

  • Hannah Christensen & Hareth Al-Janabi & Pierre Levy & Maarten J. Postma & David E. Bloom & Paolo Landa & Oliver Damm & David M. Salisbury & Javier Diez-Domingo & Adrian K. Towse & Paula K. Lorgelly & , 2020. "Economic evaluation of meningococcal vaccines: considerations for the future," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(2), pages 297-309, March.
  • Handle: RePEc:spr:eujhec:v:21:y:2020:i:2:d:10.1007_s10198-019-01129-z
    DOI: 10.1007/s10198-019-01129-z
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    1. Bernhard Ultsch & Oliver Damm & Philippe Beutels & Joke Bilcke & Bernd Brüggenjürgen & Andreas Gerber-Grote & Wolfgang Greiner & Germaine Hanquet & Raymond Hutubessy & Mark Jit & Mirjam Knol & Rüdiger, 2016. "Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community," PharmacoEconomics, Springer, vol. 34(3), pages 227-244, March.
    2. Nancy J. Devlin & Richard Brooks, 2017. "EQ-5D and the EuroQol Group: Past, Present and Future," Applied Health Economics and Health Policy, Springer, vol. 15(2), pages 127-137, April.
    3. LUYTEN, Jeroen & KESSELS, Roselinde & GOOS, Peter & BEUTELS, Philippe, 2013. "Public preferences for prioritizing preventive and curative health care interventions: A discrete choice experiment," Working Papers 2013032, University of Antwerp, Faculty of Business and Economics.
    4. Christopher James Sampson & Tim Wrightson, 2017. "Model Registration: A Call to Action," PharmacoEconomics - Open, Springer, vol. 1(2), pages 73-77, June.
    5. Alan Williams, 1997. "Intergenerational Equity: An Exploration of the ‘Fair Innings’ Argument," Health Economics, John Wiley & Sons, Ltd., vol. 6(2), pages 117-132, March.
    6. Hernandez-Villafuerte, K. & Shah, K. & Herdman, M. & Lorgelly, P., 2020. "Meningococcal Vaccines: An International Comparison of Decision-Making Processes, Frameworks and Methodologies. Are Values Missing?," Consulting Reports 002249, Office of Health Economics.
    7. Paul Dolan & Rebecca Shaw & Aki Tsuchiya & Alan Williams, 2005. "QALY maximisation and people's preferences: a methodological review of the literature," Health Economics, John Wiley & Sons, Ltd., vol. 14(2), pages 197-208, February.
    8. Gemma Lasseter & Hareth Al-Janabi & Caroline L Trotter & Fran E Carroll & Hannah Christensen, 2018. "The views of the general public on prioritising vaccination programmes against childhood diseases: A qualitative study," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-18, June.
    9. Hareth Al‐Janabi & Job Van Exel & Werner Brouwer & Caroline Trotter & Linda Glennie & Laurie Hannigan & Joanna Coast, 2016. "Measuring Health Spillovers for Economic Evaluation: A Case Study in Meningitis," Health Economics, John Wiley & Sons, Ltd., vol. 25(12), pages 1529-1544, December.
    10. James O’Mahony & Anthony Newall & Joost Rosmalen, 2015. "Dealing with Time in Health Economic Evaluation: Methodological Issues and Recommendations for Practice," PharmacoEconomics, Springer, vol. 33(12), pages 1255-1268, December.
    11. Gary M. Ginsberg & Colin Block & Chen Stein-Zamir, 2016. "Cost-utility analysis of a nationwide vaccination programme against serogroup B meningococcal disease in Israel," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 61(6), pages 683-692, July.
    12. Gu, Yuanyuan & Lancsar, Emily & Ghijben, Peter & Butler, James RG & Donaldson, Cam, 2015. "Attributes and weights in health care priority setting: A systematic review of what counts and to what extent," Social Science & Medicine, Elsevier, vol. 146(C), pages 41-52.
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    More about this item

    Keywords

    Meningitis; Meningococcal; Vaccine; Cost-effectiveness; QALY;
    All these keywords.

    JEL classification:

    • I - Health, Education, and Welfare
    • I - Health, Education, and Welfare

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    Access and download statistics

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