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Cost-utility analysis of a nationwide vaccination programme against serogroup B meningococcal disease in Israel

Author

Listed:
  • Gary M. Ginsberg

    (Public Health Service, Ministry of Health)

  • Colin Block

    (Hadassah-Hebrew University Medical Centre)

  • Chen Stein-Zamir

    (Jerusalem District Health Office, Ministry of Health
    The Hebrew University and Hadassah)

Abstract

Objectives Using cost-utility analysis, to evaluate whether or not to adopt a Neisseria meningitidis serogroup B vaccination programme for Israeli children. Methods Epidemiological, demographic, health service utilisation and economic data were integrated into a spreadsheet model to calculate the cost per averted disability-adjusted life year (DALY) of the intervention. Results Assuming 78 % vaccine efficacy with no herd immunity, vaccination will prevent 223 cases and 22 deaths over a 100-year period. Based on vaccine price of $60 per dose, total intervention costs ($315,400,000) are partially offset by a $22,700,000 reduction in treatment and sequelae costs as a result of decreased morbidity. The intervention was not cost-effective since the net cost ($292,700,000) per averted DALY gained (1249 mostly due to decreased mortality) was $234,394. Additional two dose catch-up programmes vaccinating children in cohorts aged 1–2 to 1–13 were also not cost-effective. Conclusions The vaccination will become cost-effective if vaccine costs fall below $19.44 per dose. However, in identified high risk areas, the vaccine would be cost-effective and could be recommended for use both with and without catch-up campaigns.

Suggested Citation

  • Gary M. Ginsberg & Colin Block & Chen Stein-Zamir, 2016. "Cost-utility analysis of a nationwide vaccination programme against serogroup B meningococcal disease in Israel," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 61(6), pages 683-692, July.
    • Handle: RePEc:spr:ijphth:v:61:y:2016:i:6:d:10.1007_s00038-016-0821-0
    DOI: 10.1007/s00038-016-0821-0
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    References listed on IDEAS

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    1. Given, Ruth S., 1996. "Economies of scale and scope as an explanation of merger and output diversification activities in the health maintenance organization industry," Journal of Health Economics, Elsevier, vol. 15(6), pages 685-713, December.
    2. Caroline L. Trotter & W. John Edmunds, 2006. "Reassessing the Cost-Effectiveness of Meningococcal Serogroup C Conjugate (MCC) Vaccines Using a Transmission Dynamic Model," Medical Decision Making, , vol. 26(1), pages 38-47, January.
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    1. Hannah Christensen & Hareth Al-Janabi & Pierre Levy & Maarten J. Postma & David E. Bloom & Paolo Landa & Oliver Damm & David M. Salisbury & Javier Diez-Domingo & Adrian K. Towse & Paula K. Lorgelly & , 2020. "Economic evaluation of meningococcal vaccines: considerations for the future," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(2), pages 297-309, March.

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