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Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis

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  • Samantha C Lean
  • Hayley Derricott
  • Rebecca L Jones
  • Alexander E P Heazell

Abstract

Background: Advanced maternal age (AMA; ≥35 years) is an increasing trend and is reported to be associated with various pregnancy complications. Objective: To determine the risk of stillbirth and other adverse pregnancy outcomes in women of AMA. Search strategy: Embase, Medline (Ovid), Cochrane Database of Systematic Reviews, ClinicalTrials.gov, LILACS and conference proceedings were searched from ≥2000. Selection criteria: Cohort and case-control studies reporting data on one or more co-primary outcomes (stillbirth or fetal growth restriction (FGR)) and/or secondary outcomes in mothers ≥35 years and

Suggested Citation

  • Samantha C Lean & Hayley Derricott & Rebecca L Jones & Alexander E P Heazell, 2017. "Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0186287
    DOI: 10.1371/journal.pone.0186287
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    References listed on IDEAS

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    1. Ross J. Harris & Michael J. Bradburn & Jonathan J. Deeks & Roger M. Harbord & Douglas G. Altman & Jonathan A. C. Sterne, 2008. "metan: fixed- and random-effects meta-analysis," Stata Journal, StataCorp LP, vol. 8(1), pages 3-28, February.
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    Cited by:

    1. Xiaoyu Zhang & Jun Zhang & Uma M Reddy, 2020. "Women’s Childbearing Age Associated with Optimal Fetal and Infant Outcomes: A Population-Based Study," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 8(1), pages 7-112:8, August.
    2. Abdul-Aziz Seidu & Bright Opoku Ahinkorah & Edward Kwabena Ameyaw & Amu Hubert & Wonder Agbemavi & Ebenezer Kwesi Armah-Ansah & Eugene Budu & Francis Sambah & Vivian Tackie, 2020. "What has women’s reproductive health decision-making capacity and other factors got to do with pregnancy termination in sub-Saharan Africa? evidence from 27 cross-sectional surveys," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-17, July.
    3. Hvide, Hans K. & Salvanes, Kjell G & Johnsen, Julian, 2021. "Parental Age and Birth Defects: A Sibling Study," CEPR Discussion Papers 15836, C.E.P.R. Discussion Papers.
    4. Wonjin Kim & Soo Kyung Park & Yoo Lee Kim, 2019. "Gestational diabetes mellitus diagnosed at 24 to 28 weeks of gestation in older and obese Women: Is it too late?," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-16, December.

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