IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0126368.html
   My bibliography  Save this article

Female Adolescents with Severe Substance and Conduct Problems Have Substantially Less Brain Gray Matter Volume

Author

Listed:
  • Manish S Dalwani
  • Mary Agnes McMahon
  • Susan K Mikulich-Gilbertson
  • Susan E Young
  • Michael F Regner
  • Kristen M Raymond
  • Shannon K McWilliams
  • Marie T Banich
  • Jody L Tanabe
  • Thomas J Crowley
  • Joseph T Sakai

Abstract

Objective: Structural neuroimaging studies have demonstrated lower regional gray matter volume in adolescents with severe substance and conduct problems. These research studies, including ours, have generally focused on male-only or mixed-sex samples of adolescents with conduct and/or substance problems. Here we compare gray matter volume between female adolescents with severe substance and conduct problems and female healthy controls of similar ages. Hypotheses: Female adolescents with severe substance and conduct problems will show significantly less gray matter volume in frontal regions critical to inhibition (i.e. dorsolateral prefrontal cortex and ventrolateral prefrontal cortex), conflict processing (i.e., anterior cingulate), valuation of expected outcomes (i.e., medial orbitofrontal cortex) and the dopamine reward system (i.e. striatum). Methods: We conducted whole-brain voxel-based morphometric comparison of structural MR images of 22 patients (14-18 years) with severe substance and conduct problems and 21 controls of similar age using statistical parametric mapping (SPM) and voxel-based morphometric (VBM8) toolbox. We tested group differences in regional gray matter volume with analyses of covariance, adjusting for age and IQ at p

Suggested Citation

  • Manish S Dalwani & Mary Agnes McMahon & Susan K Mikulich-Gilbertson & Susan E Young & Michael F Regner & Kristen M Raymond & Shannon K McWilliams & Marie T Banich & Jody L Tanabe & Thomas J Crowley & , 2015. "Female Adolescents with Severe Substance and Conduct Problems Have Substantially Less Brain Gray Matter Volume," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-19, May.
    • Handle: RePEc:plo:pone00:0126368
    DOI: 10.1371/journal.pone.0126368
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126368
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0126368&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0126368?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. repec:cup:judgdm:v:1:y:2006:i::p:48-63 is not listed on IDEAS
    2. Foster, E.M. & Jones, D.E. & Greenberg, M.I., 2005. "The high costs of aggression: Public expenditures resulting from conduct disorder," American Journal of Public Health, American Public Health Association, vol. 95(10), pages 1767-1772.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nora Maria Raschle & Willeke Martine Menks & Lynn Valérie Fehlbaum & Ebongo Tshomba & Christina Stadler, 2015. "Structural and Functional Alterations in Right Dorsomedial Prefrontal and Left Insular Cortex Co-Localize in Adolescents with Aggressive Behaviour: An ALE Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-24, September.
    2. Peter K Boulos & Manish S Dalwani & Jody Tanabe & Susan K Mikulich-Gilbertson & Marie T Banich & Thomas J Crowley & Joseph T Sakai, 2016. "Brain Cortical Thickness Differences in Adolescent Females with Substance Use Disorders," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-20, April.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. E. Michael Foster & Michele M. Porter & Tim S. Ayers & Debra L. Kaplan & Irwin Sandler, 2007. "Estimating the Costs of Preventive Interventions," Evaluation Review, , vol. 31(3), pages 261-286, June.
    2. Annis Lai Chu Fung, 2021. "The Significance of Family Structure in Internalizing (Anxious/Depressed) and Externalizing (Aggressive/Delinquent) Problems among Chinese Adolescents," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 16(6), pages 2403-2418, December.
    3. Stutzman, Stephen V. & Bean, Roy A. & Miller, Richard B. & Day, Randall D. & Feinauer, Leslie L. & Porter, Chris L. & Moore, Adam, 2011. "Marital conflict and adolescent outcomes: A cross-ethnic group comparison of Latino and European American youth," Children and Youth Services Review, Elsevier, vol. 33(5), pages 663-668, May.
    4. Havlicek, Judy R. & Garcia, Antonio R. & Smith, Douglas C., 2013. "Mental health and substance use disorders among foster youth transitioning to adulthood: Past research and future directions," Children and Youth Services Review, Elsevier, vol. 35(1), pages 194-203.
    5. Knapp, Martin & King, Derek & Healey, Andrew & Thomas, Cicely, 2011. "Economic outcomes in adulthood and their associations with antisocial conduct, attention deficit and anxiety problems in childhood," LSE Research Online Documents on Economics 38200, London School of Economics and Political Science, LSE Library.
    6. Martha Ellen Wynne & Ashley E. Ausikaitis & Mary Satchwell, 2013. "Adult Outcomes for Children and Adolescents With EBD," SAGE Open, , vol. 3(1), pages 21582440134, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0126368. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.