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Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis

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  • Malavika A Subramanyam
  • Ana V Diez-Roux
  • J Richard Pilsner
  • Eduardo Villamor
  • Kathleen M Donohue
  • Yongmei Liu
  • Nancy S Jenny

Abstract

Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study of Atherosclerosis Stress Study (N = 988) to describe age- and gender- independent associations of race/ethnicity and socioeconomic status (SES) with methylation of Alu and LINE-1 repetitive elements in leukocyte DNA. Mean Alu and Line 1 methylation in the full sample were 24% and 81% respectively. In multivariable linear regression models, African-Americans had 0.27% (p

Suggested Citation

  • Malavika A Subramanyam & Ana V Diez-Roux & J Richard Pilsner & Eduardo Villamor & Kathleen M Donohue & Yongmei Liu & Nancy S Jenny, 2013. "Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0054018
    DOI: 10.1371/journal.pone.0054018
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    1. Braveman, P.A. & Cubbin, C. & Egerter, S. & Williams, D.R. & Pamuk, E., 2010. "Socioeconomic disparities in health in the united States: What the patterns tell us," American Journal of Public Health, American Public Health Association, vol. 100(S1), pages 186-196.
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