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Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Author

Listed:
  • Mary M. Barker

    (Karolinska Institutet)

  • Kadri Kõiv

    (University of Tartu)

  • Ingibjörg Magnúsdóttir

    (University of Iceland)

  • Hannah Milbourn

    (University of Edinburgh)

  • Bin Wang

    (Norwegian Institute of Public Health
    Norwegian Institute of Public Health)

  • Xinkai Du

    (University of Oslo
    Modum Bad Psychiatric Hospital and Research Center)

  • Gillian Murphy

    (Karolinska Institutet)

  • Eva Herweijer

    (Karolinska Institutet)

  • Elísabet U. Gísladóttir

    (Karolinska Institutet)

  • Huiqi Li

    (University of Gothenburg)

  • Anikó Lovik

    (Karolinska Institutet
    Leiden University)

  • Anna K. Kähler

    (Karolinska Institutet
    Karolinska Institutet)

  • Archie Campbell

    (University of Edinburgh)

  • Maria Feychting

    (Karolinska Institutet)

  • Arna Hauksdóttir

    (University of Iceland)

  • Emily E. Joyce

    (Karolinska Institutet)

  • Edda Bjork Thordardottir

    (University of Iceland)

  • Emma M. Frans

    (Karolinska Institutet)

  • Asle Hoffart

    (University of Oslo
    Modum Bad Psychiatric Hospital and Research Center)

  • Reedik Mägi

    (University of Tartu)

  • Gunnar Tómasson

    (University of Iceland
    University Hospital)

  • Kristjana Ásbjörnsdóttir

    (University of Iceland)

  • Jóhanna Jakobsdóttir

    (University of Iceland)

  • Ole A. Andreassen

    (University of Oslo
    Oslo University Hospital)

  • Patrick F. Sullivan

    (Karolinska Institutet
    University of North Carolina at Chapel Hill)

  • Sverre Urnes Johnson

    (University of Oslo
    Modum Bad Psychiatric Hospital and Research Center)

  • Thor Aspelund

    (University of Iceland)

  • Ragnhild Eek Brandlistuen

    (Norwegian Institute of Public Health
    Norwegian Institute of Public Health)

  • Helga Ask

    (Norwegian Institute of Public Health
    University of Oslo)

  • Daniel L. McCartney

    (University of Edinburgh)

  • Omid V. Ebrahimi

    (University of Oslo
    University of Oxford)

  • Kelli Lehto

    (University of Tartu)

  • Unnur A. Valdimarsdóttir

    (Karolinska Institutet
    University of Iceland
    Harvard University)

  • Fredrik Nyberg

    (University of Gothenburg)

  • Fang Fang

    (Karolinska Institutet)

Abstract

Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Using data from seven cohort studies (N = 325,298) included in the multinational COVIDMENT consortium, and the Swedish registers (N = 8,080,234), this study investigates the association between mental illness (defined using self-report measures, clinical diagnosis and prescription data) and COVID-19 vaccination uptake. Results from the COVIDMENT cohort studies were pooled using meta-analyses, the majority of which showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first and second dose of a COVID-19 vaccine among individuals with vs. without mental illness; the reduction was however greater among those not using psychiatric medication. Here we show that uptake of the COVID-19 vaccine is generally high among individuals both with and without mental illness, however the lower levels of vaccination uptake observed among subgroups of individuals with unmedicated mental illness warrants further attention.

Suggested Citation

  • Mary M. Barker & Kadri Kõiv & Ingibjörg Magnúsdóttir & Hannah Milbourn & Bin Wang & Xinkai Du & Gillian Murphy & Eva Herweijer & Elísabet U. Gísladóttir & Huiqi Li & Anikó Lovik & Anna K. Kähler & Arc, 2024. "Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52342-1
    DOI: 10.1038/s41467-024-52342-1
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    References listed on IDEAS

    as
    1. Thomas Hale & Noam Angrist & Rafael Goldszmidt & Beatriz Kira & Anna Petherick & Toby Phillips & Samuel Webster & Emily Cameron-Blake & Laura Hallas & Saptarshi Majumdar & Helen Tatlow, 2021. "A global panel database of pandemic policies (Oxford COVID-19 Government Response Tracker)," Nature Human Behaviour, Nature, vol. 5(4), pages 529-538, April.
    2. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    3. Edouard Mathieu & Hannah Ritchie & Esteban Ortiz-Ospina & Max Roser & Joe Hasell & Cameron Appel & Charlie Giattino & Lucas Rodés-Guirao, 2021. "A global database of COVID-19 vaccinations," Nature Human Behaviour, Nature, vol. 5(7), pages 947-953, July.
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