IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i14p2521-d248363.html
   My bibliography  Save this article

The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis

Author

Listed:
  • Ka Young Kim

    (Department of Nursing, College of Nursing, Gachon University, 191 Hambakmoeiro, Yeonsu-gu, Incheon City 21936, Korea)

  • Eunil Lee

    (Department of Preventive Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea)

  • Yanghee Kim

    (Department of Preventive Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea)

Abstract

Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children.

Suggested Citation

  • Ka Young Kim & Eunil Lee & Yanghee Kim, 2019. "The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis," IJERPH, MDPI, vol. 16(14), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:14:p:2521-:d:248363
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/14/2521/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/14/2521/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Hye Ah Lee & Young Ju Kim & Hwayoung Lee & Hye Sun Gwak & Eun Ae Park & Su Jin Cho & Hae Soon Kim & Eun Hee Ha & Hyesook Park, 2013. "Effect of Urinary Bisphenol A on Androgenic Hormones and Insulin Resistance in Preadolescent Girls: A Pilot Study from the Ewha Birth & Growth Cohort," IJERPH, MDPI, vol. 10(11), pages 1-13, November.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sabrina Tait & Fabrizia Carli & Luca Busani & Demetrio Ciociaro & Veronica Della Latta & Annalisa Deodati & Enrica Fabbrizi & Anna Paola Pala & Francesca Maranghi & Roberta Tassinari & Giacomo Toffol , 2021. "Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project," IJERPH, MDPI, vol. 18(22), pages 1-15, November.
    2. Jong-Joo Kim & Surendra Kumar & Vinay Kumar & Yun-Mi Lee & You-Sam Kim & Vijay Kumar, 2019. "Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability," IJERPH, MDPI, vol. 17(1), pages 1-18, December.
    3. Fiorella Lucarini & Tropoja Krasniqi & Gaëlle Bailat Rosset & Nicolas Roth & Nancy B Hopf & Marie-Christine Broillet & Davide Staedler, 2020. "Exposure to New Emerging Bisphenols Among Young Children in Switzerland," IJERPH, MDPI, vol. 17(13), pages 1-15, July.
    4. Elsi Haverinen & Mariana F. Fernandez & Vicente Mustieles & Hanna Tolonen, 2021. "Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects," IJERPH, MDPI, vol. 18(24), pages 1-19, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. İlkay Unay-Gailhard & Mark A. Brennen, 2022. "How digital communications contribute to shaping the career paths of youth: a review study focused on farming as a career option," Agriculture and Human Values, Springer;The Agriculture, Food, & Human Values Society (AFHVS), vol. 39(4), pages 1491-1508, December.
    2. Mahin Ghafari & Vali Baigi & Zahra Cheraghi & Amin Doosti-Irani, 2016. "The Prevalence of Asymptomatic Bacteriuria in Iranian Pregnant Women: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-10, June.
    3. Santos Urbina & Sofía Villatoro & Jesús Salinas, 2021. "Self-Regulated Learning and Technology-Enhanced Learning Environments in Higher Education: A Scoping Review," Sustainability, MDPI, vol. 13(13), pages 1-12, June.
    4. Nadine Desrochers & Adèle Paul‐Hus & Jen Pecoskie, 2017. "Five decades of gratitude: A meta‐synthesis of acknowledgments research," Journal of the Association for Information Science & Technology, Association for Information Science & Technology, vol. 68(12), pages 2821-2833, December.
    5. Maryono, Maryono & Killoes, Aditya Marendra & Adhikari, Rajendra & Abdul Aziz, Ammar, 2024. "Agriculture development through multi-stakeholder partnerships in developing countries: A systematic literature review," Agricultural Systems, Elsevier, vol. 213(C).
    6. Alene Sze Jing Yong & Yi Heng Lim & Mark Wing Loong Cheong & Ednin Hamzah & Siew Li Teoh, 2022. "Willingness-to-pay for cancer treatment and outcome: a systematic review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(6), pages 1037-1057, August.
    7. Agnieszka A. Tubis & Katarzyna Grzybowska, 2022. "In Search of Industry 4.0 and Logistics 4.0 in Small-Medium Enterprises—A State of the Art Review," Energies, MDPI, vol. 15(22), pages 1-26, November.
    8. García-Poole, Chloe & Byrne, Sonia & Rodrigo, María José, 2019. "How do communities intervene with adolescents at psychosocial risk? A systematic review of positive development programs," Children and Youth Services Review, Elsevier, vol. 99(C), pages 194-209.
    9. Qing Ye & Bao-Xin Qian & Wei-Li Yin & Feng-Mei Wang & Tao Han, 2016. "Association between the HFE C282Y, H63D Polymorphisms and the Risks of Non-Alcoholic Fatty Liver Disease, Liver Cirrhosis and Hepatocellular Carcinoma: An Updated Systematic Review and Meta-Analysis o," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-17, September.
    10. Bishal Mohindru & David Turner & Tracey Sach & Diana Bilton & Siobhan Carr & Olga Archangelidi & Arjun Bhadhuri & Jennifer A. Whitty, 2020. "Health State Utility Data in Cystic Fibrosis: A Systematic Review," PharmacoEconomics - Open, Springer, vol. 4(1), pages 13-25, March.
    11. Neal R. Haddaway & Matthew J. Page & Chris C. Pritchard & Luke A. McGuinness, 2022. "PRISMA2020: An R package and Shiny app for producing PRISMA 2020‐compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis," Campbell Systematic Reviews, John Wiley & Sons, vol. 18(2), June.
    12. Ding Zhu & Mindan Wu & Yuan Cao & Shihua Lin & Nanxia Xuan & Chen Zhu & Wen Li & Huahao Shen, 2018. "Heated humidification did not improve compliance of positive airway pressure and subjective daytime sleepiness in obstructive sleep apnea syndrome: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-16, December.
    13. Pelai, Ricardo & Hagerman, Shannon M. & Kozak, Robert, 2020. "Biotechnologies in agriculture and forestry: Governance insights from a comparative systematic review of barriers and recommendations," Forest Policy and Economics, Elsevier, vol. 117(C).
    14. Wesam Salah Alaloul & Muhammad Altaf & Muhammad Ali Musarat & Muhammad Faisal Javed & Amir Mosavi, 2021. "Systematic Review of Life Cycle Assessment and Life Cycle Cost Analysis for Pavement and a Case Study," Sustainability, MDPI, vol. 13(8), pages 1-38, April.
    15. Joesri Mohamad Saber & Kardina Kamaruddin, 2025. "A Bibliometric Analysis of Training, Competencies, and Job Readiness in the Hotel and Tourism Industry: Trends and Future Directions," International Journal of Research and Innovation in Social Science, International Journal of Research and Innovation in Social Science (IJRISS), vol. 9(14), pages 282-297, February.
    16. Claudia Peters & Agnessa Kozak & Albert Nienhaus & Anja Schablon, 2020. "Risk of Occupational Latent Tuberculosis Infection among Health Personnel Measured by Interferon-Gamma Release Assays in Low Incidence Countries—A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(2), pages 1-16, January.
    17. Sehee Kim & Mihyeon Park & Sukhee Ahn, 2022. "The Impact of Antepartum Depression and Postpartum Depression on Exclusive Breastfeeding: A Systematic Review and Meta-Analysis," Clinical Nursing Research, , vol. 31(5), pages 866-880, June.
    18. Habarurema Jean Baptiste & Yan Guang Cai & A. Y. M. Atiquil Islam & Nzabalirwa Wenceslas, 2022. "A Systematic Review of University Social Responsibility in Post-Conflict Societies: The Case of the Great Lakes Region of East Africa," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 164(1), pages 439-475, November.
    19. Yafei Shen & Weide Shao, 2022. "Influence of Hybrid Pedagogical Models on Learning Outcomes in Physical Education: A Systematic Literature Review," IJERPH, MDPI, vol. 19(15), pages 1-16, August.
    20. Nicola Andreij Rieg & Birgitta Gatersleben & Ian Christie, 2021. "Organizational Change Management for Sustainability in Higher Education Institutions: A Systematic Quantitative Literature Review," Sustainability, MDPI, vol. 13(13), pages 1-18, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:14:p:2521-:d:248363. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.