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The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis

Author

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  • Ka Young Kim

    (Department of Nursing, College of Nursing, Gachon University, 191 Hambakmoeiro, Yeonsu-gu, Incheon City 21936, Korea)

  • Eunil Lee

    (Department of Preventive Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea)

  • Yanghee Kim

    (Department of Preventive Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea)

Abstract

Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children.

Suggested Citation

  • Ka Young Kim & Eunil Lee & Yanghee Kim, 2019. "The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis," IJERPH, MDPI, vol. 16(14), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:14:p:2521-:d:248363
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    References listed on IDEAS

    as
    1. Hye Ah Lee & Young Ju Kim & Hwayoung Lee & Hye Sun Gwak & Eun Ae Park & Su Jin Cho & Hae Soon Kim & Eun Hee Ha & Hyesook Park, 2013. "Effect of Urinary Bisphenol A on Androgenic Hormones and Insulin Resistance in Preadolescent Girls: A Pilot Study from the Ewha Birth & Growth Cohort," IJERPH, MDPI, vol. 10(11), pages 1-13, November.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    Cited by:

    1. Jong-Joo Kim & Surendra Kumar & Vinay Kumar & Yun-Mi Lee & You-Sam Kim & Vijay Kumar, 2019. "Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability," IJERPH, MDPI, vol. 17(1), pages 1-18, December.
    2. Sabrina Tait & Fabrizia Carli & Luca Busani & Demetrio Ciociaro & Veronica Della Latta & Annalisa Deodati & Enrica Fabbrizi & Anna Paola Pala & Francesca Maranghi & Roberta Tassinari & Giacomo Toffol , 2021. "Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project," IJERPH, MDPI, vol. 18(22), pages 1-15, November.
    3. Fiorella Lucarini & Tropoja Krasniqi & Gaëlle Bailat Rosset & Nicolas Roth & Nancy B Hopf & Marie-Christine Broillet & Davide Staedler, 2020. "Exposure to New Emerging Bisphenols Among Young Children in Switzerland," IJERPH, MDPI, vol. 17(13), pages 1-15, July.
    4. Elsi Haverinen & Mariana F. Fernandez & Vicente Mustieles & Hanna Tolonen, 2021. "Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects," IJERPH, MDPI, vol. 18(24), pages 1-19, December.

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