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Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Author

Listed:
  • Elsi Haverinen

    (Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), 00300 Helsinki, Finland)

  • Mariana F. Fernandez

    (Department of Radiology, School of Medicine, University of Granada, 18016 Granada, Spain
    Center of Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain
    Consortium for Biomedical Research and Epidemiology & Public Health (CIBERESP), 28029 Madrid, Spain)

  • Vicente Mustieles

    (Department of Radiology, School of Medicine, University of Granada, 18016 Granada, Spain
    Center of Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain
    Consortium for Biomedical Research and Epidemiology & Public Health (CIBERESP), 28029 Madrid, Spain)

  • Hanna Tolonen

    (Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), 00300 Helsinki, Finland)

Abstract

Increasing prevalence of metabolic syndrome (MetS) is causing a significant health burden among the European population. Current knowledge supports the notion that endocrine-disrupting chemicals (EDCs) interfere with human metabolism and hormonal balance, contributing to the conventionally recognized lifestyle-related MetS risk factors. This review aims to identify epidemiological studies focusing on the association between MetS or its individual components (e.g., obesity, insulin resistance, diabetes, dyslipidemia and hypertension) and eight HBM4EU priority substances (bisphenol A (BPA), per- and polyfluoroalkyl substances (PFASs), phthalates, polycyclic aromatic hydrocarbons (PAHs), pesticides and heavy metals (cadmium, arsenic and mercury)). Thus far, human biomonitoring (HBM) studies have presented evidence supporting the role of EDC exposures on the development of individual MetS components. The strength of the association varies between the components and EDCs. Current evidence on metabolic disturbances and EDCs is still limited and heterogeneous, and mainly represent studies from North America and Asia, highlighting the need for well-conducted and harmonized HBM programmes among the European population. Rigorous and ongoing HBM in combination with health monitoring can help to identify the most concerning EDC exposures, to guide future risk assessment and policy actions.

Suggested Citation

  • Elsi Haverinen & Mariana F. Fernandez & Vicente Mustieles & Hanna Tolonen, 2021. "Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects," IJERPH, MDPI, vol. 18(24), pages 1-19, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:13047-:d:699637
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    References listed on IDEAS

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    1. Yeon A. Kim & Joon Beom Park & Min Seok Woo & Sang Yeob Lee & Hye Young Kim & Young Hyun Yoo, 2019. "Persistent Organic Pollutant-Mediated Insulin Resistance," IJERPH, MDPI, vol. 16(3), pages 1-14, February.
    2. Ka Young Kim & Eunil Lee & Yanghee Kim, 2019. "The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis," IJERPH, MDPI, vol. 16(14), pages 1-9, July.
    3. Min Joo Kim & Shinje Moon & Byung-Chul Oh & Dawoon Jung & Kyunghee Ji & Kyungho Choi & Young Joo Park, 2018. "Association between perfluoroalkyl substances exposure and thyroid function in adults: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-17, May.
    4. Kristen M. Rappazzo & Evan Coffman & Erin P. Hines, 2017. "Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature," IJERPH, MDPI, vol. 14(7), pages 1-22, June.
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    2. Ya-Ling Shih & Chia-Jung Hsieh & Tso-Ying Lee & Pei-Hung Liao & Hao-Ting Wu & Chieh-Yu Liu, 2022. "Sex Differences between Urinary Phthalate Metabolites and Metabolic Syndrome in Adults: A Cross-Sectional Taiwan Biobank Study," IJERPH, MDPI, vol. 19(16), pages 1-18, August.

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