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The Alarming Effects of Per- and Polyfluoroalkyl Substances (PFAS) on One Health and Interconnections with Food-Producing Animals in Circular and Sustainable Agri-Food Systems

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  • Gerald C. Shurson

    (Department of Animal Science, University of Minnesota, St. Paul, MN 55108, USA)

Abstract

Per- and polyfluoroalkyl substances (PFAS) are synthetically produced chemicals that are causing a major One Health crisis. These “forever chemicals” are widely distributed globally in air, water, and soil, and because they are highly mobile and extremely difficult to degrade in the environment. They cause additional health concerns in a circular bioeconomy and food system that recycles and reuses by-products and numerous types of waste materials. Uptake of PFAS by plants and food-producing animals ultimately leads to the consumption of PFAS-contaminated food that is associated with numerous adverse health and developmental effects in humans. Contaminated meat, milk, and eggs are some of the main sources of human PFAS exposure. Although there is no safe level of PFAS exposure, maximum tolerable PFAS consumption guidelines have been established for some countries. However, there is no international PFAS monitoring system, and there are no standardized international guidelines and mechanisms to prevent the consumption of PFAS-contaminated foods. Urgent action is needed to stop PFAS production except for critical uses, implementing effective water-purification treatments, preventing spreading sewage sludge on land and pastures used to produce food, and requiring marketers and manufacturers to use packaging that is free of PFAS.

Suggested Citation

  • Gerald C. Shurson, 2025. "The Alarming Effects of Per- and Polyfluoroalkyl Substances (PFAS) on One Health and Interconnections with Food-Producing Animals in Circular and Sustainable Agri-Food Systems," Sustainability, MDPI, vol. 17(15), pages 1-41, July.
    • Handle: RePEc:gam:jsusta:v:17:y:2025:i:15:p:6957-:d:1714312
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    References listed on IDEAS

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    1. Gehui Wang & Jianjiang Lu & Zhenni Xing & Shanman Li & Zilong Liu & Yanbin Tong, 2017. "Occurrence, Distribution, and Risk Assessment of Perfluoroalkyl Acids (PFAAs) in Muscle and Liver of Cattle in Xinjiang, China," IJERPH, MDPI, vol. 14(9), pages 1-15, August.
    2. Nicole Marie Brennan & Abigail Teresa Evans & Meredith Kate Fritz & Stephanie Allison Peak & Haley Elizabeth von Holst, 2021. "Trends in the Regulation of Per- and Polyfluoroalkyl Substances (PFAS): A Scoping Review," IJERPH, MDPI, vol. 18(20), pages 1-28, October.
    3. Gaurav Jha & Vanaja Kankarla & Everald McLennon & Suman Pal & Debjani Sihi & Biswanath Dari & Dawson Diaz & Mallika Nocco, 2021. "Per- and Polyfluoroalkyl Substances (PFAS) in Integrated Crop–Livestock Systems: Environmental Exposure and Human Health Risks," IJERPH, MDPI, vol. 18(23), pages 1-20, November.
    4. Zygmunt M. Gusiatin & Dorota Kulikowska & Barbara Klik, 2020. "New-Generation Washing Agents in Remediation of Metal-Polluted Soils and Methods for Washing Effluent Treatment: A Review," IJERPH, MDPI, vol. 17(17), pages 1-19, August.
    5. David Trudel & Lea Horowitz & Matthias Wormuth & Martin Scheringer & Ian T. Cousins & Konrad Hungerbühler, 2008. "Estimating Consumer Exposure to PFOS and PFOA," Risk Analysis, John Wiley & Sons, vol. 28(2), pages 251-269, April.
    6. Chao-Yu Shen & Jun-Cheng Weng & Jeng-Dau Tsai & Pen-Hua Su & Ming-Chih Chou & Shu-Li Wang, 2021. "Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI," IJERPH, MDPI, vol. 18(9), pages 1-16, April.
    7. Chen-Yu Liu & Pau-Chung Chen & Pei-Chen Lien & Yi-Peng Liao, 2018. "Prenatal Perfluorooctyl Sulfonate Exposure and Alu DNA Hypomethylation in Cord Blood," IJERPH, MDPI, vol. 15(6), pages 1-10, May.
    8. Kristen M. Rappazzo & Evan Coffman & Erin P. Hines, 2017. "Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature," IJERPH, MDPI, vol. 14(7), pages 1-22, June.
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