Author
Listed:
- Hye Ah Lee
(Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
- Young Ju Kim
(Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
- Hwayoung Lee
(Department of Anatomy, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
- Hye Sun Gwak
(Colleage of Pharmacy, Ewha Womans University, Seoul 120-750, Korea)
- Eun Ae Park
(Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
- Su Jin Cho
(Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
- Hae Soon Kim
(Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
- Eun Hee Ha
(Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
- Hyesook Park
(Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea)
Abstract
To assess the effect of urinary bisphenol A (BPA) on repeated measurements of androgenic hormones and metabolic indices, we used multivariate analysis of variance (MANOVA) adjusted for potential confounders at baseline. During July to August 2011, 80 preadolescent girls enrolled in the Ewha Birth & Growth Cohort study participated in a follow-up study and then forty-eight of them (60.0%) came back one year later. Baseline levels of estradiol and androstenedione were higher in the BPA group than in the non-BPA group. One year later, girls in the high BPA exposure group showed higher levels of androstenedione, testosterone, estradiol, and insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index, than those in the other groups ( p < 0.05). In MANOVA, estradiol and androstenedione showed significant differences among groups, while dehydroepiandrosterone, insulin, and HOMA-IR showed marginally significant differences. Exposure to BPA may affect endocrine metabolism in preadolescents. However, further investigation is required to elucidate the mechanisms linking BPA with regulation of androgenic hormones.
Suggested Citation
Hye Ah Lee & Young Ju Kim & Hwayoung Lee & Hye Sun Gwak & Eun Ae Park & Su Jin Cho & Hae Soon Kim & Eun Hee Ha & Hyesook Park, 2013.
"Effect of Urinary Bisphenol A on Androgenic Hormones and Insulin Resistance in Preadolescent Girls: A Pilot Study from the Ewha Birth & Growth Cohort,"
IJERPH, MDPI, vol. 10(11), pages 1-13, November.
Handle:
RePEc:gam:jijerp:v:10:y:2013:i:11:p:5737-5749:d:30104
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