Vaccine innovation, translational research and the management of knowledge accumulation
What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving processes that generate knowledge which is often fragmented and only locally valid. This paper details some of the conditions that allow fragmented, local knowledge to accumulate through a series of structured steps from the artificial simplicity of the laboratory to the complexity of real world application. Poliomyelitis is used as an illustrative case to highlight the importance of experimental animal models and the extent of co-ordination that can be required if they are missing. Implications for the governance and management of current attempts to produce vaccines for HIV, TB and Malaria are discussed.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 75 (2012)
Issue (Month): 12 ()
|Contact details of provider:|| Web page: http://www.elsevier.com/wps/find/journaldescription.cws_home/315/description#description|
|Order Information:|| Postal: http://www.elsevier.com/wps/find/supportfaq.cws_home/regional|
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Nichter, Mark, 1995. "Vaccinations in the third world: A consideration of community demand," Social Science & Medicine, Elsevier, vol. 41(5), pages 617-632, September.
- Jean O. Lanjouw, 2003. "Intellectual Property and the Availability of Pharmaceuticals in Poor Countries," NBER Chapters, in: Innovation Policy and the Economy, Volume 3, pages 91-130 National Bureau of Economic Research, Inc.
- Blume, Stuart S., 2005. "Lock in, the state and vaccine development: Lessons from the history of the polio vaccines," Research Policy, Elsevier, vol. 34(2), pages 159-173, March.
- Bryder, Linda, 1999. "'We shall not find salvation in inoculation': BCG vaccination in Scandinavia, Britain and the USA, 1921-1960," Social Science & Medicine, Elsevier, vol. 49(9), pages 1157-1167, November.
- Bonu, Sekhar & Rani, Manju & Baker, Timothy D., 2003. "The impact of the national polio immunization campaign on levels and equity in immunization coverage: evidence from rural North India," Social Science & Medicine, Elsevier, vol. 57(10), pages 1807-1819, November.
- Poltorak, Mike & Leach, Melissa & Fairhead, James & Cassell, Jackie, 2005. "'MMR talk' and vaccination choices: An ethnographic study in Brighton," Social Science & Medicine, Elsevier, vol. 61(3), pages 709-719, August.
- Archibugi, Daniele & .Kim Bizzarri, 2004.
"Committing to Vaccine R&D: A Global Science Policy Priority/Comprometerse en la investigación y desarrollo de vacunas: una prioridad de la política científica global,"
Estudios de Economía Aplicada,
Estudios de Economía Aplicada, vol. 22, pages 251-271, Agosto.
- Archibugi, Daniele & Bizzarri, Kim, 2004. "Committing to vaccine R&D: a global science policy priority," Research Policy, Elsevier, vol. 33(10), pages 1657-1671, December.
- Nelson, Richard R. & Buterbaugh, Kristin & Perl, Marcel & Gelijns, Annetine, 2011. "How medical know-how progresses," Research Policy, Elsevier, vol. 40(10), pages 1339-1344.
- Blume, Stuart & Tump, Janneke, 2010. "Evidence and policymaking: The introduction of MMR vaccine in the Netherlands," Social Science & Medicine, Elsevier, vol. 71(6), pages 1049-1055, September.
- Blume, Stuart & Zanders, Mariska, 2006. "Vaccine independence, local competences and globalisation: Lessons from the history of pertussis vaccines," Social Science & Medicine, Elsevier, vol. 63(7), pages 1825-1835, October.
- Richard R. Nelson, 2008. "Factors affecting the power of technological paradigms," Industrial and Corporate Change, Oxford University Press, vol. 17(3), pages 485-497, June.
- Blume, Stuart, 2006. "Anti-vaccination movements and their interpretations," Social Science & Medicine, Elsevier, vol. 62(3), pages 628-642, February.
- Mays, Rose M. & Sturm, Lynne A. & Zimet, Gregory D., 2004. "Parental perspectives on vaccinating children against sexually transmitted infections," Social Science & Medicine, Elsevier, vol. 58(7), pages 1405-1413, April.
- Dosi, Giovanni, 1993.
"Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change,"
Elsevier, vol. 22(2), pages 102-103, April.
- Dosi, Giovanni, 1982. "Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change," Research Policy, Elsevier, vol. 11(3), pages 147-162, June.
- Nightingale, Paul, 2004. "Technological capabilities, invisible infrastructure and the un-social construction of predictability: the overlooked fixed costs of useful research," Research Policy, Elsevier, vol. 33(9), pages 1259-1284, November.
- Bastien, Joseph W., 1995. "Cross cultural communication of tetanus vaccinations in Bolivia," Social Science & Medicine, Elsevier, vol. 41(1), pages 77-86, July.
When requesting a correction, please mention this item's handle: RePEc:eee:socmed:v:75:y:2012:i:12:p:2143-2150. See general information about how to correct material in RePEc.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Shamier, Wendy)
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If references are entirely missing, you can add them using this form.
If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.
Please note that corrections may take a couple of weeks to filter through the various RePEc services.