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Optimizing vaccination facility locations and capacity for pandemic response: A case study of Mashhad, Iran

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  • Kheybari, Siamak
  • Mehrpour, Mohammad Reza
  • Moradi, Nima
  • Scaparra, Maria Paola

Abstract

Strategic and tactical issues must be considered when determining the location of facilities for service provision during healthcare crises. This paper introduces a systematic multi-step approach for selecting the location of immunization centers and warehouses for medical supplies during a pandemic. Initially, the relevant strategic criteria encompassing infrastructure, environmental, and socio-demographic dimensions are identified from the literature. Expert opinions are then solicited through the Best-Worst Method to assess the importance of each criterion. In the third step, a Geographic Information System is employed to identify potential locations and their strategic cost based on these criteria. Finally, a Two-Echelon Capacitated Location Allocation Problem (2E-CLAP), integrating fairness and capacity considerations, is formulated to select optimal sites based on strategic costs utilizing the principles of the classic p-center and set covering problems. The model is solved using an enhanced multi-objective Genetic Algorithm. The methodology is validated through a case study to identify the location of vaccination facilities in Mashhad, Iran. The findings underscore the capability of the proposed approach to alleviate patient congestion at vaccination centers while concurrently optimizing the strategic criteria and ensuring comprehensive coverage for all city residents.

Suggested Citation

  • Kheybari, Siamak & Mehrpour, Mohammad Reza & Moradi, Nima & Scaparra, Maria Paola, 2026. "Optimizing vaccination facility locations and capacity for pandemic response: A case study of Mashhad, Iran," International Journal of Production Economics, Elsevier, vol. 292(C).
    • Handle: RePEc:eee:proeco:v:292:y:2026:i:c:s0925527325003500
    DOI: 10.1016/j.ijpe.2025.109865
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    1. Aianna Rios Magalhães Véras e Silva & Bruna de Freitas Iwata & Maria do Socorro Ferreira dos Santos & José Machado Moita Neto, 2023. "Impacts and Regulations of Healthcare Solid Waste Management during the COVID-19 Pandemic: A Systematic Review," Sustainability, MDPI, vol. 15(19), pages 1-19, October.
    2. Dastgoshade, Sohaib & Shafiee, Mohammad & Klibi, Walid & Shishebori, Davood, 2022. "Social equity-based distribution networks design for the COVID-19 vaccine," International Journal of Production Economics, Elsevier, vol. 250(C).
    3. Tang, Lianhua & Li, Yantong & Bai, Danyu & Liu, Tao & Coelho, Leandro C., 2022. "Bi-objective optimization for a multi-period COVID-19 vaccination planning problem," Omega, Elsevier, vol. 110(C).
    4. Burcin Bozkaya & Giuseppe Bruno & Ioannis Giannikos, 2019. "Location and Geographic Information Systems," Springer Books, in: Gilbert Laporte & Stefan Nickel & Francisco Saldanha da Gama (ed.), Location Science, edition 2, chapter 0, pages 559-590, Springer.
    5. Abdin, Adam F. & Fang, Yi-Ping & Caunhye, Aakil & Alem, Douglas & Barros, Anne & Zio, Enrico, 2023. "An optimization model for planning testing and control strategies to limit the spread of a pandemic – The case of COVID-19," European Journal of Operational Research, Elsevier, vol. 304(1), pages 308-324.
    6. Merve Yilmaz & Aslı Ulubaş Hamurcu, 2022. "Relationships between socio-demographic structure and spatio-temporal distribution patterns of COVID-19 cases in Istanbul, Turkey," International Journal of Urban Sciences, Taylor & Francis Journals, vol. 26(4), pages 557-581, October.
    7. Xu, Jing & Murray, Alan T. & Church, Richard L. & Wei, Ran, 2023. "Service allocation equity in location coverage analytics," European Journal of Operational Research, Elsevier, vol. 305(1), pages 21-37.
    8. Chuanlin Ning & Han Wang & Jing Wu & Qinwei Chen & Huacheng Pei & Hao Gao, 2022. "The COVID-19 Vaccination and Vaccine Inequity Worldwide: An Empirical Study Based on Global Data," IJERPH, MDPI, vol. 19(9), pages 1-13, April.
    9. Constantine Toregas & Ralph Swain & Charles ReVelle & Lawrence Bergman, 1971. "The Location of Emergency Service Facilities," Operations Research, INFORMS, vol. 19(6), pages 1363-1373, October.
    10. Shishebori, Davood & Yousefi Babadi, Abolghasem, 2015. "Robust and reliable medical services network design under uncertain environment and system disruptions," Transportation Research Part E: Logistics and Transportation Review, Elsevier, vol. 77(C), pages 268-288.
    11. Xueping Li & Zhaoxia Zhao & Xiaoyan Zhu & Tami Wyatt, 2011. "Covering models and optimization techniques for emergency response facility location and planning: a review," Mathematical Methods of Operations Research, Springer;Gesellschaft für Operations Research (GOR);Nederlands Genootschap voor Besliskunde (NGB), vol. 74(3), pages 281-310, December.
    12. Evrim Didem Güneş & Teresa Melo & Stefan Nickel, 2019. "Location Problems in Healthcare," Springer Books, in: Gilbert Laporte & Stefan Nickel & Francisco Saldanha da Gama (ed.), Location Science, edition 2, chapter 0, pages 657-686, Springer.
    13. Muhammet Gul & Ali Fuat Guneri, 2021. "Hospital Location Selection: A Systematic Literature Review on Methodologies and Applications," Mathematical Problems in Engineering, Hindawi, vol. 2021, pages 1-14, February.
    14. Yang, Yuwen & Bidkhori, Hoda & Rajgopal, Jayant, 2021. "Optimizing vaccine distribution networks in low and middle-income countries," Omega, Elsevier, vol. 99(C).
    15. Sourour Elloumi & Martine Labbé & Yves Pochet, 2004. "A New Formulation and Resolution Method for the p-Center Problem," INFORMS Journal on Computing, INFORMS, vol. 16(1), pages 84-94, February.
    16. Li, Xin & Pan, Yanchun & Jiang, Shiqiang & Huang, Qiang & Chen, Zhimin & Zhang, Mingxia & Zhang, Zuoyao, 2021. "Locate vaccination stations considering travel distance, operational cost, and work schedule," Omega, Elsevier, vol. 101(C).
    17. Areej Alhothali & Budoor Alwated & Kamil Faisal & Sultanah Alshammari & Reem Alotaibi & Nusaybah Alghanmi & Omaimah Bamasag & Manal Bin Yamin, 2022. "Location-Allocation Model to Improve the Distribution of COVID-19 Vaccine Centers in Jeddah City, Saudi Arabia," IJERPH, MDPI, vol. 19(14), pages 1-21, July.
    18. Fahrettin Eldemir & Ismail Onden, 2016. "Geographical Information Systems and Multicriteria Decisions Integration Approach for Hospital Location Selection," International Journal of Information Technology & Decision Making (IJITDM), World Scientific Publishing Co. Pte. Ltd., vol. 15(05), pages 975-997, September.
    19. Rezaei, Jafar, 2015. "Best-worst multi-criteria decision-making method," Omega, Elsevier, vol. 53(C), pages 49-57.
    20. Yusuf Kuvvetli, 2023. "A goal programming model for two-stage COVID19 test sampling centers location-allocation problem," Central European Journal of Operations Research, Springer;Slovak Society for Operations Research;Hungarian Operational Research Society;Czech Society for Operations Research;Österr. Gesellschaft für Operations Research (ÖGOR);Slovenian Society Informatika - Section for Operational Research;Croatian Operational Research Society, vol. 31(1), pages 1-20, March.
    21. F. Antonio Medrano, 2020. "The complete vertex p-center problem," EURO Journal on Computational Optimization, Springer;EURO - The Association of European Operational Research Societies, vol. 8(3), pages 327-343, October.
    22. S. L. Hakimi, 1965. "Optimum Distribution of Switching Centers in a Communication Network and Some Related Graph Theoretic Problems," Operations Research, INFORMS, vol. 13(3), pages 462-475, June.
    23. Grot, Matthias, 2024. "Decision support framework for tactical emergency medical service location planning," Omega, Elsevier, vol. 125(C).
    24. Govindan, Kannan & Salehian, Farhad & Kian, Hadi & Hosseini, Seyed Teimoor & Mina, Hassan, 2023. "A location-inventory-routing problem to design a circular closed-loop supply chain network with carbon tax policy for achieving circular economy: An augmented epsilon-constraint approach," International Journal of Production Economics, Elsevier, vol. 257(C).
    25. Dell’Ovo, Marta & Capolongo, Stefano & Oppio, Alessandra, 2018. "Combining spatial analysis with MCDA for the siting of healthcare facilities," Land Use Policy, Elsevier, vol. 76(C), pages 634-644.
    26. Sohrab Faramarzi-Oghani & Parisa Dolati Neghabadi & El-Ghazali Talbi & Reza Tavakkoli-Moghaddam, 2023. "Meta-heuristics for sustainable supply chain management: a review," International Journal of Production Research, Taylor & Francis Journals, vol. 61(6), pages 1979-2009, March.
    27. Yarmand, Hamed & Ivy, Julie S. & Denton, Brian & Lloyd, Alun L., 2014. "Optimal two-phase vaccine allocation to geographically different regions under uncertainty," European Journal of Operational Research, Elsevier, vol. 233(1), pages 208-219.
    28. Manupati, Vijaya Kumar & Schoenherr, Tobias & Subramanian, Nachiappan & Ramkumar, M. & Soni, Bhanushree & Panigrahi, Suraj, 2021. "A multi-echelon dynamic cold chain for managing vaccine distribution," Transportation Research Part E: Logistics and Transportation Review, Elsevier, vol. 156(C).
    29. Ceren Erdin & Halil Emre Akbaş, 2019. "A Comparative Analysis of Fuzzy TOPSIS and Geographic Information Systems (GIS) for the Location Selection of Shopping Malls: A Case Study from Turkey," Sustainability, MDPI, vol. 11(14), pages 1-22, July.
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