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D- and I-optimal design of mixture experiments in the presence of ingredient availability constraints

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  • SYAFITRI, Utami
  • SARTONO, Bagus
  • GOOS, Peter

Abstract

Mixture experiments usually involve various constraints on the proportions of the ingredients of the mixture under study. In this paper, inspired by the fact that the available stock of certain ingredients is often limited, we focus on a new type of constraint, which we refer to as an ingredient availability constraint. This type of constraint substantially complicates the search for optimal designs for mixture experiments. One difficulty, for instance, is that the optimal number of experimental runs is not known a priori. We show that the optimal design problem in the presence of ingredient availability constraints is a nonlinear multidimensional knapsack problem and propose a variable neighborhood descent algorithm to identify D- and I-optimal designs for mixture experiments in case there is a limited stock of certain ingredients.

Suggested Citation

  • SYAFITRI, Utami & SARTONO, Bagus & GOOS, Peter, 2015. "D- and I-optimal design of mixture experiments in the presence of ingredient availability constraints," Working Papers 2015003, University of Antwerp, Faculty of Business and Economics.
  • Handle: RePEc:ant:wpaper:2015003
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    References listed on IDEAS

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    6. GOOS, Peter & JONES, Bradley & SYAFITRI, Utami, 2013. "I-optimal mixture designs," Working Papers 2013033, University of Antwerp, Faculty of Business and Economics.
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    11. DE KETELAERE, Bart & GOOS, Peter & BRIJS, Kristof, 2010. "Prespecified factor-level combinations in the optimal design of mixture-process variable experiments," Working Papers 2011001, University of Antwerp, Faculty of Business and Economics.
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    Cited by:

    1. VÁZQUEZ-ALCOCER, Alan & GOOS, Peter & SCHOEN, Eric D., 2016. "Two-level designs constructed by concatenating orthogonal arrays of strenght three," Working Papers 2016011, University of Antwerp, Faculty of Business and Economics.
    2. VÁZQUEZ-ALCOCER, Alan & XU, Hongquan, 2018. "Construction of two-level nonregular designs of strength three with large run sizes," Working Papers 2018003, University of Antwerp, Faculty of Business and Economics.

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