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Mapping between EQ‐5D‐3L and EQ‐5D‐5L: A survey experiment on the validity of multi‐instrument data

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  • Mónica Hernández‐Alava
  • Stephen Pudney

Abstract

EQ‐5D is a 5‐item questionnaire instrument designed to measure health‐related quality of life. It is extremely important, since it is used to measure health benefits in many studies providing evidence for reimbursement decisions by the National Institute for Health and Care Excellence in England and similar policy bodies in other countries. EQ‐5D has been redesigned in a more detailed form (EQ‐5D‐5L), but much existing cost‐effectiveness evidence is based on the older version (EQ‐5D‐3L). Statistical mapping from one version to another is widely used, exploiting data from multi‐instrument surveys incorporating both variants. However, little is known about the robustness of data from such multi‐instrument surveys. We design a randomized experiment to investigate whether inclusion of both versions at different stages in a single interview gives a reliable picture of the relationship between health measures from the two instruments and embed it in individual interviews from the UK Understanding Society household panel. We find that sequencing of the two versions of EQ‐5D within an interview has a significant impact not only on the resulting data but also on the estimated mapping models. We illustrate the non‐negligible effects in two real‐world cost‐effectiveness examples and discuss the implications for future multi‐instrument survey design.

Suggested Citation

  • Mónica Hernández‐Alava & Stephen Pudney, 2022. "Mapping between EQ‐5D‐3L and EQ‐5D‐5L: A survey experiment on the validity of multi‐instrument data," Health Economics, John Wiley & Sons, Ltd., vol. 31(6), pages 923-939, June.
    • Handle: RePEc:wly:hlthec:v:31:y:2022:i:6:p:923-939
    DOI: 10.1002/hec.4487
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    References listed on IDEAS

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    1. Hausman, J. A. & Abrevaya, Jason & Scott-Morton, F. M., 1998. "Misclassification of the dependent variable in a discrete-response setting," Journal of Econometrics, Elsevier, vol. 87(2), pages 239-269, September.
    2. Monica Hernandez Alava & Allan Wailoo, 2015. "Fitting adjusted limited dependent variable mixture models to EQ-5D," Stata Journal, StataCorp LLC, vol. 15(3), pages 737-750, September.
    3. Nancy J. Devlin & Koonal K. Shah & Yan Feng & Brendan Mulhern & Ben van Hout, 2018. "Valuing health‐related quality of life: An EQ‐5D‐5L value set for England," Health Economics, John Wiley & Sons, Ltd., vol. 27(1), pages 7-22, January.
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