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A Review of Generic Preference-Based Measures for Use in Cost-Effectiveness Models


  • John Brazier

    (University of Sheffield)

  • Roberta Ara

    (University of Sheffield)

  • Donna Rowen

    (University of Sheffield)

  • Helene Chevrou-Severac

    (Takeda Pharmaceuticals International AG)


Generic preference-based measures (GPBMs) of health are used to obtain the quality adjustment weight required to calculate the quality-adjusted life year in health economic models. GPBMs have been developed to use across different interventions and medical conditions and typically consist of a self-complete patient questionnaire, a health state classification system, and preference weights for all states defined by the classification system. Of the six main GPBMs, the three most frequently used are the Health Utilities Index version 3, the EuroQol 5 dimensions (3 and 5 levels), and the Short Form 6 dimensions. There are considerable differences in GPBMs in terms of the content and size of descriptive systems (i.e. the numbers of dimensions of health and levels of severity within these), the methods of valuation [e.g. time trade-off (TTO), standard gamble (SG)], and the populations (e.g. general population, patients) used to value the health states within the descriptive systems. Although GPBMs are anchored at 1 (full health) and 0 (dead), they produce different health state utility values when completed by the same patient. Considerations when selecting a measure for use in a clinical trial include practicality, reliability, validity and responsiveness. Requirements of reimbursement agencies may impose additional restrictions on suitable measures for use in economic evaluations, such as the valuation technique (TTO, SG) or the source of values (general public vs. patients).

Suggested Citation

  • John Brazier & Roberta Ara & Donna Rowen & Helene Chevrou-Severac, 2017. "A Review of Generic Preference-Based Measures for Use in Cost-Effectiveness Models," PharmacoEconomics, Springer, vol. 35(1), pages 21-31, December.
  • Handle: RePEc:spr:pharme:v:35:y:2017:i:1:d:10.1007_s40273-017-0545-x
    DOI: 10.1007/s40273-017-0545-x

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    References listed on IDEAS

    1. Samer A. Kharroubi & Anthony O'Hagan & John E. Brazier, 2005. "Estimating utilities from individual health preference data: a nonparametric Bayesian method," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 54(5), pages 879-895, November.
    2. Louise Longworth & Stirling Bryan, 2003. "An empirical comparison of EQ‐5D and SF‐6D in liver transplant patients," Health Economics, John Wiley & Sons, Ltd., vol. 12(12), pages 1061-1067, December.
    3. Richard Norman & Paula Cronin & Rosalie Viney, 2013. "A Pilot Discrete Choice Experiment to Explore Preferences for EQ-5D-5L Health States," Applied Health Economics and Health Policy, Springer, vol. 11(3), pages 287-298, June.
    4. Rosalie Viney & Richard Norman & John Brazier & Paula Cronin & Madeleine T. King & Julie Ratcliffe & Deborah Street, 2014. "An Australian Discrete Choice Experiment To Value Eq‐5d Health States," Health Economics, John Wiley & Sons, Ltd., vol. 23(6), pages 729-742, June.
    5. Nancy J. Devlin & Koonal K. Shah & Yan Feng & Brendan Mulhern & Ben van Hout, 2018. "Valuing health‐related quality of life: An EQ‐5D‐5L value set for England," Health Economics, John Wiley & Sons, Ltd., vol. 27(1), pages 7-22, January.
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    Cited by:

    1. Roberta Ara & John Brazier & Tracey Young, 2017. "Recommended Methods for the Collection of Health State Utility Value Evidence in Clinical Studies," PharmacoEconomics, Springer, vol. 35(1), pages 67-75, December.
    2. Jonathan Karnon, 2017. "Heath State Utility Values for Cost-Effectiveness Models," PharmacoEconomics, Springer, vol. 35(1), pages 1-3, December.
    3. Roberta Ara & John Brazier & Tessa Peasgood & Suzy Paisley, 2017. "The Identification, Review and Synthesis of Health State Utility Values from the Literature," PharmacoEconomics, Springer, vol. 35(1), pages 43-55, December.
    4. Donna Rowen & John Brazier & Roberta Ara & Ismail Azzabi Zouraq, 2017. "The Role of Condition-Specific Preference-Based Measures in Health Technology Assessment," PharmacoEconomics, Springer, vol. 35(1), pages 33-41, December.
    5. Pickles, Kristen & Lancsar, Emily & Seymour, Janelle & Parkin, David & Donaldson, Cam & Carter, Stacy M., 2019. "Accounts from developers of generic health state utility instruments explain why they produce different QALYs: A qualitative study," Social Science & Medicine, Elsevier, vol. 240(C).

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