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The added value of the cognition, dining, gastrointestinal problems, sleep and tiredness bolt-on dimensions to the EQ-5D-5L in patients with coeliac disease

Author

Listed:
  • M. Mercédesz Angyal

    (Semmelweis University Doctoral School
    Corvinus University of Budapest)

  • Mathieu F. Janssen

    (Erasmus MC)

  • Péter L. Lakatos

    (McGill University Health Centre, Montreal General Hospital
    Semmelweis University)

  • Valentin Brodszky

    (Corvinus University of Budapest)

  • Fanni Rencz

    (Semmelweis University Doctoral School
    Corvinus University of Budapest)

Abstract

Objectives Multiple studies suggest that the EQ-5D may overestimate health-related quality of life (HRQoL) in patients with coeliac disease (CD). We aimed to develop and psychometrically test potentially relevant bolt-on dimensions to improve the measurement performance of the EQ-5D-5L in CD patients. Methods The development and selection of bolt-ons were informed by a literature review on HRQoL in CD, expert and patient input. A cross-sectional online survey was conducted amongst 312 adult CD patients. Respondents completed the EQ-5D-5L, two condition-specific bolt-ons newly-developed for the present study [dining (DI) and gastrointestinal problems (GI)] and three existing bolt-ons [cognition (CO), sleep (SL) and tiredness (TI)]. The following psychometric properties were tested: ceiling, informativity, convergent and known-group validity, and dimensionality (confirmatory factor analysis). Results Adding the TI, SL, GI, DI and CO individual bolt-ons reduced the ceiling of the EQ-5D-5L (39%) to 17%, 23%, 24%, 26% and 37%, respectively. GI excelled with strong convergent validity with the Gastrointestinal Symptom Rating Scale total score (rs=0.71) and improved the discriminatory power for all known-groups. GI was the only bolt-on loading on a different factor from the five core dimensions, whereas the other four bolt-ons loaded onto the same ‘psychosocial health’ factor as the EQ-5D-5L anxiety/depression dimension. Conclusion The DI, GI, SL and TI bolt-ons, especially the GI, enhance the validity of EQ-5D-5L in patients with CD, suggesting their value in capturing important HRQoL aspects potentially missed by the five core dimensions. These bolt-ons can be used in sensitivity analyses supporting health technology assessments and subsequent resource allocation decisions.

Suggested Citation

  • M. Mercédesz Angyal & Mathieu F. Janssen & Péter L. Lakatos & Valentin Brodszky & Fanni Rencz, 2025. "The added value of the cognition, dining, gastrointestinal problems, sleep and tiredness bolt-on dimensions to the EQ-5D-5L in patients with coeliac disease," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 26(3), pages 473-485, April.
    • Handle: RePEc:spr:eujhec:v:26:y:2025:i:3:d:10.1007_s10198-024-01719-6
    DOI: 10.1007/s10198-024-01719-6
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    References listed on IDEAS

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    1. John Horn, 1965. "A rationale and test for the number of factors in factor analysis," Psychometrika, Springer;The Psychometric Society, vol. 30(2), pages 179-185, June.
    2. Yaling Yang & John Brazier & Aki Tsuchiya, 2014. "Effect of Adding a Sleep Dimension to the EQ-5D Descriptive System," Medical Decision Making, , vol. 34(1), pages 42-53, January.
    3. McDonald, Rebecca & Mullett, Timothy L. & Tsuchiya, Aki, 2020. "Understanding the composite dimensions of the EQ-5D: An experimental approach," Social Science & Medicine, Elsevier, vol. 265(C).
    4. John Brazier & Roberta Ara & Donna Rowen & Helene Chevrou-Severac, 2017. "A Review of Generic Preference-Based Measures for Use in Cost-Effectiveness Models," PharmacoEconomics, Springer, vol. 35(1), pages 21-31, December.
    5. Martine Hoogendoorn & Mark Oppe & Melinde R. S. Boland & Lucas M. A. Goossens & Elly A. Stolk & Maureen P. M. H. Rutten–van Mölken, 2019. "Exploring the Impact of Adding a Respiratory Dimension to the EQ-5D-5L," Medical Decision Making, , vol. 39(4), pages 393-404, May.
    6. Jeff Richardson & Munir A. Khan & Angelo Iezzi & Aimee Maxwell, 2015. "Comparing and Explaining Differences in the Magnitude, Content, and Sensitivity of Utilities Predicted by the EQ-5D, SF-6D, HUI 3, 15D, QWB, and AQoL-8D Multiattribute Utility Instruments," Medical Decision Making, , vol. 35(3), pages 276-291, April.
    7. Matthew Kennedy-Martin & Bernhard Slaap & Michael Herdman & Mandy Reenen & Tessa Kennedy-Martin & Wolfgang Greiner & Jan Busschbach & Kristina S. Boye, 2020. "Which multi-attribute utility instruments are recommended for use in cost-utility analysis? A review of national health technology assessment (HTA) guidelines," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(8), pages 1245-1257, November.
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