IDEAS home Printed from https://ideas.repec.org/a/spr/hecrev/v10y2020i1d10.1186_s13561-020-00297-6.html
   My bibliography  Save this article

Application study of the EQ-5D-5L in oncology: linking self-reported quality of life of patients with advanced or metastatic colorectal cancer to clinical data from a German tumor registry

Author

Listed:
  • Kathrin Borchert

    (Xcenda GmbH)

  • Christian Jacob

    (Xcenda GmbH)

  • Natalie Wetzel

    (iOMEDICO AG)

  • Martina Jänicke

    (iOMEDICO AG)

  • Egbert Eggers

    (Kreiskrankenhaus Torgau)

  • Annette Sauer

    (Medizinisches Versorgungszentrum für Blut- und Krebserkrankungen)

  • Norbert Marschner

    (Praxis für interdisziplinäre Onkologie und Hämatologie)

  • Julia Altevers

    (Xcenda GmbH)

  • Thomas Mittendorf

    (Xcenda GmbH)

  • Wolfgang Greiner

    (Universität Bielefeld)

Abstract

Background The EQ-5D-5L questionnaire is used in oncology to generate health-related quality of life (HRQoL) weights and corresponding health states. The purpose was to explore the relationship between demographic and clinical characteristics and HRQoL among advanced or metastatic colorectal cancer (CRC) patients by linking clinical data of a German CRC registry to self-reported HRQoL measures from the EQ-5D-5L. Methods The study sample included patients with advanced or metastatic CRC currently recruited in the German Tumor Registry Colorectal Cancer. The EQ-5D-5L was administered once to patients who were at the start or at later stages of palliative treatment. Data on comorbidities, disease-specific health states, symptoms, and treatment status were drawn from the registry. Multivariate regression analyses were performed to explore the impact of patient and disease characteristics on HRQoL. Results In total, n = 433 questionnaires were included in the data analysis. Mean age of patients was 66.3 years and 61.2% were male. The mean EQ-5D-5L utility score was 0.82 and the mean EQ-5D-5L VAS score was 62.05. The regression analyses revealed that none of the demographic characteristics and few of the clinical characteristics, such as fatigue and pain, had a significant impact on the HRQoL. Conclusions The study demonstrated a reduced HRQoL of patients with advanced or metastatic CRC when compared to the general population. The symptoms fatigue and pain negatively affected the HRQoL, whereas other characteristics such as age, gender, and comorbidities did not have a significant impact on HRQoL.

Suggested Citation

  • Kathrin Borchert & Christian Jacob & Natalie Wetzel & Martina Jänicke & Egbert Eggers & Annette Sauer & Norbert Marschner & Julia Altevers & Thomas Mittendorf & Wolfgang Greiner, 2020. "Application study of the EQ-5D-5L in oncology: linking self-reported quality of life of patients with advanced or metastatic colorectal cancer to clinical data from a German tumor registry," Health Economics Review, Springer, vol. 10(1), pages 1-14, December.
  • Handle: RePEc:spr:hecrev:v:10:y:2020:i:1:d:10.1186_s13561-020-00297-6
    DOI: 10.1186/s13561-020-00297-6
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1186/s13561-020-00297-6
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1186/s13561-020-00297-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Daniela Eidt-Koch & Thomas Wagner & Thomas Mittendorf & J.-Matthias Schulenburg, 2010. "Outpatient medication costs of patients with cystic fibrosis in Germany," Applied Health Economics and Health Policy, Springer, vol. 8(2), pages 111-118, March.
    2. Ohrnberger, Julius & Fichera, Eleonora & Sutton, Matt, 2017. "The relationship between physical and mental health: A mediation analysis," Social Science & Medicine, Elsevier, vol. 195(C), pages 42-49.
    Full references (including those not matched with items on IDEAS)

    Citations

    Blog mentions

    As found by EconAcademics.org, the blog aggregator for Economics research:
    1. Chris Sampson’s journal round-up for 11th January 2021
      by Chris Sampson in The Academic Health Economists' Blog on 2021-01-11 12:00:06

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiang Kang & Mingxi Du & Siqin Wang & Haifeng Du, 2022. "Exploring the Effect of Health on Migrants’ Social Integration in China," IJERPH, MDPI, vol. 19(8), pages 1-20, April.
    2. Karine Chevreul & Morgane Michel & Karen Berg Brigham & Julio López-Bastida & Renata Linertová & Juan Oliva-Moreno & Pedro Serrano-Aguilar & Manuel Posada-de-la-Paz & Domenica Taruscio & Arrigo Schiep, 2016. "Social/economic costs and health-related quality of life in patients with cystic fibrosis in Europe," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 17(1), pages 7-18, April.
    3. Levinsky, Michal & Schiff, Miriam, 2021. "Lifetime cumulative adversity and physical health deterioration in old age: Evidence from a fourteen-year longitudinal study," Social Science & Medicine, Elsevier, vol. 289(C).
    4. Ernst, Mareike & Brähler, Elmar & Klein, Eva M. & Jünger, Claus & Wild, Philipp S. & Faber, Jörg & Schneider, Astrid & Beutel, Manfred E., 2020. "What's past is prologue: Recalled parenting styles are associated with childhood cancer survivors' mental health outcomes more than 25 years after diagnosis," Social Science & Medicine, Elsevier, vol. 252(C).
    5. Khayal, Inas S. & Barnato, Amber E., 2022. "What is in the palliative care ‘syringe’? A systems perspective," Social Science & Medicine, Elsevier, vol. 305(C).
    6. Grzegorz Bulczak & Alexi Gugushvili & Olga Zelinska, 2022. "How are social origin, destination and mobility linked to physical, mental, and self-rated health? Evidence from the United States," Quality & Quantity: International Journal of Methodology, Springer, vol. 56(5), pages 3555-3585, October.
    7. Rippon, Isla & Steptoe, Andrew, 2018. "Is the relationship between subjective age, depressive symptoms and activities of daily living bidirectional?," Social Science & Medicine, Elsevier, vol. 214(C), pages 41-48.
    8. Ruiz-Tagle, Jaime & Urria, Ignacio, 2022. "Household overcrowding trajectories and mental well-being," Social Science & Medicine, Elsevier, vol. 296(C).
    9. Ohrnberger, Julius & Anselmi, Laura & Fichera, Eleonora & Sutton, Matt, 2020. "The effect of cash transfers on mental health: Opening the black box – A study from South Africa," Social Science & Medicine, Elsevier, vol. 260(C).
    10. Mareike Heimeshoff & Helge Hollmeyer & Jonas Schreyögg & Oliver Tiemann & Doris Staab, 2012. "Cost of Illness of Cystic Fibrosis in Germany," PharmacoEconomics, Springer, vol. 30(9), pages 763-777, September.
    11. Yang, Liyuan & Zikos, Vasileios, 2022. "Healthy mind in healthy body: Identifying the causal effect of mental health on physical health," Economics Letters, Elsevier, vol. 213(C).
    12. Gowokani Chijere Chirwa & Marc Suhrcke & Rodrigo Moreno-Serra, 2020. "The Impact of Ghana’s National Health Insurance on Psychological Distress," Applied Health Economics and Health Policy, Springer, vol. 18(2), pages 249-259, April.
    13. Mikrut, Emilia E. & Keating, Luke H. & Barnwell, Patrick V. & Cioffi, Loriann & Vega, Destiny & Contrada, Richard J. & Brondolo, Elizabeth, 2022. "Pathways from exposure to racial/ethnic discrimination to depression: Testing a social-cognitive model," Social Science & Medicine, Elsevier, vol. 292(C).
    14. Xiuhai Xiong & Lingbo Liu & Zhenghong Peng & Hao Wu, 2021. "Physical Activities in Public Squares: The Impact of Companionship on Chinese Residents’ Health," Land, MDPI, vol. 10(7), pages 1-14, July.
    15. Aisha Jadoon & Samia Wasif & Uzma Imtiaz, 2018. "Literary Responses to the War on Terror: A Psychological Analysis," Global Social Sciences Review, Humanity Only, vol. 3(4), pages 380-388, December.
    16. Prakash, Kushneel & Awaworyi Churchill, Sefa & Smyth, Russell, 2022. "Are you puffing your Children's future away? Energy poverty and childhood exposure to passive smoking," Economic Modelling, Elsevier, vol. 114(C).
    17. Yuanyuan Gu & Sonia García-Pérez & John Massie & Kees Gool, 2015. "Cost of care for cystic fibrosis: an investigation of cost determinants using national registry data," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 16(7), pages 709-717, September.
    18. Abaigeal D. Jackson & Andrew L. Jackson & Godfrey Fletcher & Gerardine Doyle & Mary Harrington & Shijun Zhou & Fiona Cullinane & Charles Gallagher & Edward McKone, 2017. "Estimating Direct Cost of Cystic Fibrosis Care Using Irish Registry Healthcare Resource Utilisation Data, 2008–2012," PharmacoEconomics, Springer, vol. 35(10), pages 1087-1101, October.
    19. Ben Y. F. Fong & Martin C. S. Wong & Vincent T. S. Law & Man Fung Lo & Tommy K. C. Ng & Hilary H. L. Yee & Tiffany C. H. Leung & Percy W. T. Ho, 2020. "Relationships between Physical and Social Behavioural Changes and the Mental Status of Homebound Residents in Hong Kong during the COVID-19 Pandemic," IJERPH, MDPI, vol. 17(18), pages 1-18, September.
    20. Jessie X. Fan & Zhou Yu, 2022. "Prevalence and Risk Factors of Consumer Financial Fraud in China," Journal of Family and Economic Issues, Springer, vol. 43(2), pages 384-396, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:hecrev:v:10:y:2020:i:1:d:10.1186_s13561-020-00297-6. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: . General contact details of provider: http://www.springer.com/economics/journal/13561 .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/13561 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.