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The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study

Author

Listed:
  • Laura Delgado-Ortega

    (AstraZeneca Farmacéutica Spain)

  • Almudena González-Domínguez

    (Weber)

  • Josep María Borrás

    (University of Barcelona)

  • Juan Oliva-Moreno

    (Universidad de Castilla-La Mancha – Campus de Toledo)

  • Eva González-Haba

    (Hospital General Universitario Gregorio Marañón)

  • Salomón Menjón

    (Hospital Universitario Virgen de las Nieves)

  • Pedro Pérez

    (Hospital Clínico Universitario)

  • David Vicente

    (Hospital Universitario Virgen Macarena)

  • Luis Cordero

    (AstraZeneca Farmacéutica Spain)

  • Margarita Jiménez

    (Weber)

  • Susana Simón

    (AstraZeneca Farmacéutica Spain)

  • Álvaro Hidalgo-Vega

    (Universidad de Castilla-La Mancha – Campus de Toledo)

  • Carlota Moya-Alarcón

    (AstraZeneca Farmacéutica Spain)

Abstract

Objective To assess the economic burden of epithelial ovarian cancer (EOC) in incident patients and the burden by disease stage in Spain. Methods We developed a Markov model from a social perspective simulating the natural history of EOC and its four stages, with a 10-year time horizon, 3-week cycles, 3% discount rate, and 2016 euros. Healthcare resource utilization and costs were estimated by disease stage. Direct healthcare costs (DHC) included early screening, genetic counselling, medical visits, diagnostic tests, surgery, chemotherapy, hospitalizations, emergency services, and palliative care. Direct non-healthcare costs (DNHC) included formal and informal care. Indirect costs (IC) included labour productivity losses due to temporary and permanent leaves, and premature death. Epidemiology data and resource use were taken from the literature and validated for Spain by the OvarCost group using a Delphi method. Results The total burden of EOC over 10 years was 3102 mill euros: 15.1% in stage I, 3.9% in stage II, 41.0% in stage III, and 40.2% in stage IV. Annual average cost/patient was €24,111 and it was €8,641; €14,184; €33,858, and €42,547 in stages I–IV, respectively. Of total costs, 71.2% were due to DHC, 24.7% to DNHC, and 4.1% to IC. Conclusions EOC imposes a significant economic burden on the national healthcare system and society in Spain. Investment in better early diagnosis techniques might increase survival and patients’ quality of life. This would likely reduce costs derived from late stages, consequently leading to a substantial reduction of the economic burden associated with EOC.

Suggested Citation

  • Laura Delgado-Ortega & Almudena González-Domínguez & Josep María Borrás & Juan Oliva-Moreno & Eva González-Haba & Salomón Menjón & Pedro Pérez & David Vicente & Luis Cordero & Margarita Jiménez & Susa, 2019. "The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(1), pages 135-147, February.
    • Handle: RePEc:spr:eujhec:v:20:y:2019:i:1:d:10.1007_s10198-018-0986-y
    DOI: 10.1007/s10198-018-0986-y
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    References listed on IDEAS

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    1. Katharina M. D. Merollini & Louisa G. Gordon & Yiu M. Ho & Joanne F. Aitken & Michael G. Kimlin, 2022. "Cancer Survivors’ Long-Term Health Service Costs in Queensland, Australia: Results of a Population-Level Data Linkage Study (Cos-Q)," IJERPH, MDPI, vol. 19(15), pages 1-17, August.
    2. Katharina M. D. Merollini & Louisa G. Gordon & Joanne F. Aitken & Michael G. Kimlin, 2020. "Lifetime Costs of Surviving Cancer—A Queensland Study (COS-Q): Protocol of a Large Healthcare Data Linkage Study," IJERPH, MDPI, vol. 17(8), pages 1-16, April.

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