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Non-concave penalization in linear mixed-effect models and regularized selection of fixed effects

Author

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  • Abhik Ghosh

    (University of Oslo)

  • Magne Thoresen

    (University of Oslo)

Abstract

Mixed-effect models are very popular for analyzing data with a hierarchical structure. In medical applications, typical examples include repeated observations within subjects in a longitudinal design, patients nested within centers in a multicenter design. However, recently, due to the medical advances, the number of fixed-effect covariates collected from each patient can be quite large, e.g., data on gene expressions of each patient, and all of these variables are not necessarily important for the outcome. So, it is very important to choose the relevant covariates correctly for obtaining the optimal inference for the overall study. On the other hand, the relevant random effects will often be low-dimensional and pre-specified. In this paper, we consider regularized selection of important fixed-effect variables in linear mixed-effect models along with maximum penalized likelihood estimation of both fixed and random-effect parameters based on general non-concave penalties. Asymptotic and variable selection consistency with oracle properties are proved for low-dimensional cases as well as for high dimensionality of non-polynomial order of sample size (number of parameters is much larger than sample size). We also provide a suitable computationally efficient algorithm for implementation. Additionally, all the theoretical results are proved for a general non-convex optimization problem that applies to several important situations well beyond the mixed model setup (like finite mixture of regressions) illustrating the huge range of applicability of our proposal.

Suggested Citation

  • Abhik Ghosh & Magne Thoresen, 2018. "Non-concave penalization in linear mixed-effect models and regularized selection of fixed effects," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 102(2), pages 179-210, April.
    • Handle: RePEc:spr:alstar:v:102:y:2018:i:2:d:10.1007_s10182-017-0298-z
    DOI: 10.1007/s10182-017-0298-z
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    References listed on IDEAS

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    1. Howard D. Bondell & Arun Krishna & Sujit K. Ghosh, 2010. "Joint Variable Selection for Fixed and Random Effects in Linear Mixed-Effects Models," Biometrics, The International Biometric Society, vol. 66(4), pages 1069-1077, December.
    2. Lukas Meier & Sara Van De Geer & Peter Bühlmann, 2008. "The group lasso for logistic regression," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(1), pages 53-71, February.
    3. Florin Vaida & Suzette Blanchard, 2005. "Conditional Akaike information for mixed-effects models," Biometrika, Biometrika Trust, vol. 92(2), pages 351-370, June.
    4. Joseph G. Ibrahim & Hongtu Zhu & Ramon I. Garcia & Ruixin Guo, 2011. "Fixed and Random Effects Selection in Mixed Effects Models," Biometrics, The International Biometric Society, vol. 67(2), pages 495-503, June.
    5. Hua Liang & Hulin Wu & Guohua Zou, 2008. "A note on conditional aic for linear mixed-effects models," Biometrika, Biometrika Trust, vol. 95(3), pages 773-778.
    6. P. Tseng & S. Yun, 2009. "Block-Coordinate Gradient Descent Method for Linearly Constrained Nonsmooth Separable Optimization," Journal of Optimization Theory and Applications, Springer, vol. 140(3), pages 513-535, March.
    7. Friedman, Jerome H. & Hastie, Trevor & Tibshirani, Rob, 2010. "Regularization Paths for Generalized Linear Models via Coordinate Descent," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 33(i01).
    8. Rohart, Florian & San Cristobal, Magali & Laurent, Béatrice, 2014. "Selection of fixed effects in high dimensional linear mixed models using a multicycle ECM algorithm," Computational Statistics & Data Analysis, Elsevier, vol. 80(C), pages 209-222.
    9. Fan J. & Li R., 2001. "Variable Selection via Nonconcave Penalized Likelihood and its Oracle Properties," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1348-1360, December.
    10. Zhen Chen & David B. Dunson, 2003. "Random Effects Selection in Linear Mixed Models," Biometrics, The International Biometric Society, vol. 59(4), pages 762-769, December.
    11. Antoniadis A. & Fan J., 2001. "Regularization of Wavelet Approximations," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 939-967, September.
    12. A. Antoniadis, 1997. "Wavelets in statistics: A review," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 6(2), pages 97-130, August.
    13. Jianqing Fan, 1997. "Comments on «Wavelets in statistics: A review» by A. Antoniadis," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 6(2), pages 131-138, August.
    14. Pu, Wenji & Niu, Xu-Feng, 2006. "Selecting mixed-effects models based on a generalized information criterion," Journal of Multivariate Analysis, Elsevier, vol. 97(3), pages 733-758, March.
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    4. Burgard, Jan Pablo & Krause, Joscha & Schmaus, Simon, 2021. "Estimation of regional transition probabilities for spatial dynamic microsimulations from survey data lacking in regional detail," Computational Statistics & Data Analysis, Elsevier, vol. 154(C).

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