IDEAS home Printed from https://ideas.repec.org/a/eee/csdana/v80y2014icp209-222.html
   My bibliography  Save this article

Selection of fixed effects in high dimensional linear mixed models using a multicycle ECM algorithm

Author

Listed:
  • Rohart, Florian
  • San Cristobal, Magali
  • Laurent, Béatrice

Abstract

Linear mixed models are especially useful when observations are grouped. In a high dimensional setting however, selecting the fixed effect coefficients in these models is mandatory as classical tools are not performing well. By considering the random effects as missing values in the linear mixed model framework, a ℓ1-penalization on the fixed effects coefficients of the resulting log-likelihood is proposed. The optimization problem is solved via a multicycle Expectation Conditional Maximization (ECM) algorithm which allows for the number of parameters p to be larger than the total number of observations n and does not require the inversion of the sample n×n covariance matrix. The proposed algorithm can be combined with any variable selection method developed for linear models. A variant of the proposed approach replaces the ℓ1-penalization with a multiple testing procedure for the variable selection aspect and is shown to greatly improve the False Discovery Rate. Both methods are implemented in the MMS R-package, and are shown to give very satisfying results in a high-dimensional simulated setting.

Suggested Citation

  • Rohart, Florian & San Cristobal, Magali & Laurent, Béatrice, 2014. "Selection of fixed effects in high dimensional linear mixed models using a multicycle ECM algorithm," Computational Statistics & Data Analysis, Elsevier, vol. 80(C), pages 209-222.
    • Handle: RePEc:eee:csdana:v:80:y:2014:i:c:p:209-222
    DOI: 10.1016/j.csda.2014.06.022
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167947314002011
    Download Restriction: Full text for ScienceDirect subscribers only.
    File URL: https://libkey.io/10.1016/j.csda.2014.06.022?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Zou, Hui, 2006. "The Adaptive Lasso and Its Oracle Properties," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 1418-1429, December.
    2. Biernacki, Christophe & Chrétien, Stéphane, 2003. "Degeneracy in the maximum likelihood estimation of univariate Gaussian mixtures with EM," Statistics & Probability Letters, Elsevier, vol. 61(4), pages 373-382, February.
    3. Joseph G. Ibrahim & Hongtu Zhu & Ramon I. Garcia & Ruixin Guo, 2011. "Fixed and Random Effects Selection in Mixed Effects Models," Biometrics, The International Biometric Society, vol. 67(2), pages 495-503, June.
    4. Howard D. Bondell & Arun Krishna & Sujit K. Ghosh, 2010. "Joint Variable Selection for Fixed and Random Effects in Linear Mixed-Effects Models," Biometrics, The International Biometric Society, vol. 66(4), pages 1069-1077, December.
    5. Hui Zou & Trevor Hastie, 2005. "Addendum: Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(5), pages 768-768, November.
    6. Hui Zou & Trevor Hastie, 2005. "Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(2), pages 301-320, April.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mammen, Enno & Wilke, Ralf A. & Zapp, Kristina Maria, 2022. "Estimation of group structures in panel models with individual fixed effects," ZEW Discussion Papers 22-023, ZEW - Leibniz Centre for European Economic Research.
    2. Abhik Ghosh & Magne Thoresen, 2018. "Non-concave penalization in linear mixed-effect models and regularized selection of fixed effects," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 102(2), pages 179-210, April.
    3. Abrahamsen, Tavis & Hobert, James P., 2019. "Fast Monte Carlo Markov chains for Bayesian shrinkage models with random effects," Journal of Multivariate Analysis, Elsevier, vol. 169(C), pages 61-80.
    4. Simona Buscemi & Antonella Plaia, 2020. "Model selection in linear mixed-effect models," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 104(4), pages 529-575, December.
    5. Ollier, Edouard & Samson, Adeline & Delavenne, Xavier & Viallon, Vivian, 2016. "A SAEM algorithm for fused lasso penalized NonLinear Mixed Effect Models: Application to group comparison in pharmacokinetics," Computational Statistics & Data Analysis, Elsevier, vol. 95(C), pages 207-221.
    6. Caroline Bazzoli & Sophie Lambert-Lacroix & Marie-José Martinez, 2023. "Partial least square based approaches for high-dimensional linear mixed models," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 32(3), pages 769-786, September.
    7. Qi Zhang, 2022. "High-Dimensional Mediation Analysis with Applications to Causal Gene Identification," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 14(3), pages 432-451, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Simona Buscemi & Antonella Plaia, 2020. "Model selection in linear mixed-effect models," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 104(4), pages 529-575, December.
    2. Mojtaba Ganjali & Taban Baghfalaki, 2018. "Application of Penalized Mixed Model in Identification of Genes in Yeast Cell-Cycle Gene Expression Data," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 6(2), pages 38-41, April.
    3. Jan Pablo Burgard & Joscha Krause & Ralf Münnich, 2019. "Penalized Small Area Models for the Combination of Unit- and Area-level Data," Research Papers in Economics 2019-05, University of Trier, Department of Economics.
    4. Zhang, Yan-Qing & Tian, Guo-Liang & Tang, Nian-Sheng, 2016. "Latent variable selection in structural equation models," Journal of Multivariate Analysis, Elsevier, vol. 152(C), pages 190-205.
    5. Tutz, Gerhard & Pößnecker, Wolfgang & Uhlmann, Lorenz, 2015. "Variable selection in general multinomial logit models," Computational Statistics & Data Analysis, Elsevier, vol. 82(C), pages 207-222.
    6. Margherita Giuzio, 2017. "Genetic algorithm versus classical methods in sparse index tracking," Decisions in Economics and Finance, Springer;Associazione per la Matematica, vol. 40(1), pages 243-256, November.
    7. Mkhadri, Abdallah & Ouhourane, Mohamed, 2013. "An extended variable inclusion and shrinkage algorithm for correlated variables," Computational Statistics & Data Analysis, Elsevier, vol. 57(1), pages 631-644.
    8. Yize Zhao & Matthias Chung & Brent A. Johnson & Carlos S. Moreno & Qi Long, 2016. "Hierarchical Feature Selection Incorporating Known and Novel Biological Information: Identifying Genomic Features Related to Prostate Cancer Recurrence," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(516), pages 1427-1439, October.
    9. Christopher J Greenwood & George J Youssef & Primrose Letcher & Jacqui A Macdonald & Lauryn J Hagg & Ann Sanson & Jenn Mcintosh & Delyse M Hutchinson & John W Toumbourou & Matthew Fuller-Tyszkiewicz &, 2020. "A comparison of penalised regression methods for informing the selection of predictive markers," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-14, November.
    10. Norman R. Swanson & Weiqi Xiong, 2018. "Big data analytics in economics: What have we learned so far, and where should we go from here?," Canadian Journal of Economics/Revue canadienne d'économique, John Wiley & Sons, vol. 51(3), pages 695-746, August.
    11. Gareth M. James & Peter Radchenko & Jinchi Lv, 2009. "DASSO: connections between the Dantzig selector and lasso," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 71(1), pages 127-142, January.
    12. Ping Wu & Xinchao Luo & Peirong Xu & Lixing Zhu, 2017. "New variable selection for linear mixed-effects models," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 69(3), pages 627-646, June.
    13. Mostafa Rezaei & Ivor Cribben & Michele Samorani, 2021. "A clustering-based feature selection method for automatically generated relational attributes," Annals of Operations Research, Springer, vol. 303(1), pages 233-263, August.
    14. Umberto Amato & Anestis Antoniadis & Italia De Feis & Irene Gijbels, 2021. "Penalised robust estimators for sparse and high-dimensional linear models," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 30(1), pages 1-48, March.
    15. Camila Epprecht & Dominique Guegan & Álvaro Veiga & Joel Correa da Rosa, 2017. "Variable selection and forecasting via automated methods for linear models: LASSO/adaLASSO and Autometrics," Post-Print halshs-00917797, HAL.
    16. Wang Zhu & Wang C.Y., 2010. "Buckley-James Boosting for Survival Analysis with High-Dimensional Biomarker Data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 9(1), pages 1-33, June.
    17. Wang, Christina Dan & Chen, Zhao & Lian, Yimin & Chen, Min, 2022. "Asset selection based on high frequency Sharpe ratio," Journal of Econometrics, Elsevier, vol. 227(1), pages 168-188.
    18. repec:jss:jstsof:33:i01 is not listed on IDEAS
    19. Borup, Daniel & Christensen, Bent Jesper & Mühlbach, Nicolaj Søndergaard & Nielsen, Mikkel Slot, 2023. "Targeting predictors in random forest regression," International Journal of Forecasting, Elsevier, vol. 39(2), pages 841-868.
    20. Bartosz Uniejewski, 2024. "Regularization for electricity price forecasting," Papers 2404.03968, arXiv.org.
    21. Peter Bühlmann & Jacopo Mandozzi, 2014. "High-dimensional variable screening and bias in subsequent inference, with an empirical comparison," Computational Statistics, Springer, vol. 29(3), pages 407-430, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:80:y:2014:i:c:p:209-222. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/csda .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.