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Partial least square based approaches for high-dimensional linear mixed models

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Listed:
  • Caroline Bazzoli

    (Universitê Grenoble Alpes)

  • Sophie Lambert-Lacroix

    (Universitê Grenoble Alpes)

  • Marie-José Martinez

    (Universitê Grenoble Alpes)

Abstract

To deal with repeated data or longitudinal data, linear mixed effects models are commonly used. A classical parameter estimation method is the Expectation–Maximization (EM) algorithm. In this paper, we propose three new Partial Least Square (PLS) based approaches using the EM-algorithm to reduce the high-dimensional data to a lower one for fixed effects in linear mixed models. Unlike the Principal Component Regression approach, the PLS method allows to take into account the link between the outcome and the independent variables. We compare these approaches from a simulation study and a yeast cell-cycle gene expression data set. We demonstrate the performance of two of them and we recommend their use to conduct future analyses for high dimensional data in linear mixed effect models context.

Suggested Citation

  • Caroline Bazzoli & Sophie Lambert-Lacroix & Marie-José Martinez, 2023. "Partial least square based approaches for high-dimensional linear mixed models," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 32(3), pages 769-786, September.
  • Handle: RePEc:spr:stmapp:v:32:y:2023:i:3:d:10.1007_s10260-023-00685-2
    DOI: 10.1007/s10260-023-00685-2
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    References listed on IDEAS

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    1. Rohart, Florian & San Cristobal, Magali & Laurent, Béatrice, 2014. "Selection of fixed effects in high dimensional linear mixed models using a multicycle ECM algorithm," Computational Statistics & Data Analysis, Elsevier, vol. 80(C), pages 209-222.
    2. Shayle Searle, 1995. "An overview of variance component estimation," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 42(1), pages 215-230, December.
    3. Howard D. Bondell & Arun Krishna & Sujit K. Ghosh, 2010. "Joint Variable Selection for Fixed and Random Effects in Linear Mixed-Effects Models," Biometrics, The International Biometric Society, vol. 66(4), pages 1069-1077, December.
    4. Eliot Melissa & Ferguson Jane & Reilly Muredach P. & Foulkes Andrea S., 2011. "Ridge Regression for Longitudinal Biomarker Data," The International Journal of Biostatistics, De Gruyter, vol. 7(1), pages 1-11, September.
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