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The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis

Author

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  • Adam Dinoff
  • Nathan Herrmann
  • Walter Swardfager
  • Celina S Liu
  • Chelsea Sherman
  • Sarah Chan
  • Krista L Lanctôt

Abstract

Background: The mechanisms through which physical activity supports healthy brain function remain to be elucidated. One hypothesis suggests that increased brain-derived neurotrophic factor (BDNF) mediates some cognitive and mood benefits. This meta-analysis sought to determine the effect of exercise training on resting concentrations of BDNF in peripheral blood. Methods: MEDLINE, Embase, PsycINFO, SPORTDiscus, Rehabilitation & Sports Medicine Source, and CINAHL databases were searched for original, peer-reviewed reports of peripheral blood BDNF concentrations before and after exercise interventions ≥ 2 weeks. Risk of bias was assessed using standardized criteria. Standardized mean differences (SMDs) were generated from random effects models. Risk of publication bias was assessed using funnel plots and Egger’s test. Potential sources of heterogeneity were explored in subgroup analyses. Results: In 29 studies that met inclusion criteria, resting concentrations of peripheral blood BDNF were higher after intervention (SMD = 0.39, 95% CI: 0.17–0.60, p

Suggested Citation

  • Adam Dinoff & Nathan Herrmann & Walter Swardfager & Celina S Liu & Chelsea Sherman & Sarah Chan & Krista L Lanctôt, 2016. "The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-21, September.
    • Handle: RePEc:plo:pone00:0163037
    DOI: 10.1371/journal.pone.0163037
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    1. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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    Cited by:

    1. Kinga Humińska-Lisowska & Jolanta Chmielowiec & Krzysztof Chmielowiec & Marta Niewczas & Milena Lachowicz & Paweł Cięszczyk & Jolanta Masiak & Aleksandra Strońska-Pluta & Monika Michałowska-Sawczyn & , 2022. "Associations of Brain-Derived Neurotropic Factor rs6265 Gene Polymorphism with Personality Dimensions among Athletes," IJERPH, MDPI, vol. 19(15), pages 1-11, August.
    2. Joanna Jaworska & Ewa Rodziewicz-Flis & Jakub Kortas & Marta Kozłowska & Katarzyna Micielska & Anna Babińska & Radosław Laskowski & Giovanni Lombardi & Ewa Ziemann, 2020. "Short-Term Resistance Training Supported by Whole-Body Cryostimulation Induced a Decrease in Myostatin Concentration and an Increase in Isokinetic Muscle Strength," IJERPH, MDPI, vol. 17(15), pages 1-16, July.
    3. Miroslaw Babiarz & Radoslaw Laskowski & Tomasz Grzywacz, 2022. "Effects of Strength Training on BDNF in Healthy Young Adults," IJERPH, MDPI, vol. 19(21), pages 1-14, October.
    4. Lysleine Alves Deus & Hugo de Luca Corrêa & Rodrigo Vanerson Passos Neves & Andrea Lucena Reis & Fernando Sousa Honorato & Victor Lopes Silva & Michel Kendy Souza & Thaís Branquinho de Araújo & Lucas , 2021. "Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axi," IJERPH, MDPI, vol. 18(21), pages 1-13, October.
    5. Anna Piotrowska & Halina Gattner & Justyna Adamiak & Sylwia Mętel & Olga Czerwińska-Ledwig & Wanda Pilch & Ewa Sadowska-Krępa & Małgorzata Żychowska & Ivan Uher & Tomasz Pałka, 2022. "Effect of Whole-Body Vibration on Serum Levels of Brain Derived Neurotrophic Factor and Cortisol in Young, Healthy Women," IJERPH, MDPI, vol. 19(23), pages 1-11, December.
    6. Juan Antonio Zarza-Rebollo & Esther Molina & Elena López-Isac & Ana M. Pérez-Gutiérrez & Blanca Gutiérrez & Jorge A. Cervilla & Margarita Rivera, 2022. "Interaction Effect between Physical Activity and the BDNF Val66Met Polymorphism on Depression in Women from the PISMA-ep Study," IJERPH, MDPI, vol. 19(4), pages 1-13, February.
    7. Sebastian Hacker & Thomas Reichel & Anne Hecksteden & Christopher Weyh & Kristina Gebhardt & Mark Pfeiffer & Alexander Ferrauti & Michael Kellmann & Tim Meyer & Karsten Krüger, 2021. "Recovery-Stress Response of Blood-Based Biomarkers," IJERPH, MDPI, vol. 18(11), pages 1-12, May.

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