IDEAS home Printed from https://ideas.repec.org/a/plo/pntd00/0008383.html

Some searches may not work properly. We apologize for the inconvenience.

   My bibliography  Save this article

A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection

Author

Listed:
  • Ludoviko Zirimenya
  • Fatima Mahmud-Ajeigbe
  • Ruth McQuillan
  • You Li

Abstract

Background: Urogenital schistosomiasis and HIV/AIDS infections are widespread in sub-Saharan Africa (SSA) leading to substantial morbidity and mortality. The co-occurrence of both diseases has led to the possible hypothesis that urogenital schistosomiasis leads to increased risk of acquiring HIV infection. However, the available evidence concerning this association is inconsistent. The aim of this study was to systematically review and quantitatively synthesize studies that investigated the association between urogenital schistosomiasis and HIV/AIDS infection. Methods: A systematic review basing on PRISMA guidelines was conducted. It is registered with PROSPERO, number CRD42018116648. We searched four databases, MEDLINE, EMBASE, Global Health and Global Index Medicus for studies investigating the association between urogenital schistosomiasis and HIV infection. Only studies published in English were considered. Results of the association were summarised by gender. A meta-analysis was performed for studies on females using random-effects model and a pooled OR with 95% confidence interval was reported. Results: Of the 993 studies screened, only eight observational studies met the inclusion criteria. Across all studies, the reported unadjusted OR ranged from 0.78 to 3.76. The pooled estimate of unadjusted OR among females was 1.31 (95% CI: 0.87–1.99). Only four of the eight studies reported an adjusted OR. A separate meta-analysis done in the three studies among females that reported an adjusted OR showed that the pooled estimate was 1.85 (95% CI: 1.17–2.92). There were insufficient data to pool results for association between urogenital schistosomiasis and HIV infection in the males. Conclusion: Our investigation supports the hypothesis of an association between urogenital schistosomiasis with HIV/AIDS infection in females. Due to insufficient evidence, no conclusion could be drawn in males with urogenital schistosomiasis. Large-scale prospective studies are needed in future. Author summary: Urogenital schistosomiasis, caused by parasitic trematode Schistosoma haematobium is a significant source of morbidity in sub Saharan Africa. HIV infection caused by a retrovirus is of two subtypes HIV 1 and HIV 2, with subtype HIV 1 being found worldwide and more aggressive, leading to HIV/AIDS. Research on both of these diseases in the same settings, has shown that these diseases cross paths. This has led to the suggestion that there could be a possible association between the two. Here we describe a systematic review that was carried out to determine if there is an association between UGS and HIV/AIDS infections. We searched all published articles available in MEDLINE, EMBASE, Global Health (CABI), and Global Index Medicus before 28th January 2020. We found eight observational studies eligible to be included in the systematic review and no intervention study. Six of these studies were included in the meta-analysis. A summarized meta-analysis of the study findings with adjusted OR showed that there was a likely association between urogenital schistosomiasis and HIV/AIDS infections in females. However, due to limited papers in males, no conclusion could be drawn.

Suggested Citation

  • Ludoviko Zirimenya & Fatima Mahmud-Ajeigbe & Ruth McQuillan & You Li, 2020. "A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(6), pages 1-13, June.
    • Handle: RePEc:plo:pntd00:0008383
    DOI: 10.1371/journal.pntd.0008383
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008383
    Download Restriction: no
    File URL: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008383&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pntd.0008383?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sergey Yegorov & Vineet Joag & Ronald M. Galiwango & Sara V. Good & Juliet Mpendo & Egbert Tannich & Andrea K. Boggild & Noah Kiwanuka & Bernard S. Bagaya & Rupert Kaul, 2019. "Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    3. Chalotte Stecher & Per Kallestrup & Eyrun Kjetland & Birgitte Vennervald & Eskild Petersen, 2015. "Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 60(7), pages 839-848, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Trang Nguyen & Sara Holton & Thach Tran & Jane Fisher, 2019. "Informal mental health interventions for people with severe mental illness in low and lower middle-income countries: A systematic review of effectiveness," International Journal of Social Psychiatry, , vol. 65(3), pages 194-206, May.
    2. Alessandro Concari & Gerjo Kok & Pim Martens, 2020. "A Systematic Literature Review of Concepts and Factors Related to Pro-Environmental Consumer Behaviour in Relation to Waste Management Through an Interdisciplinary Approach," Sustainability, MDPI, vol. 12(11), pages 1-50, May.
    3. Damiano Pizzol & Mike Trott & Igor Grabovac & Mario Antunes & Anna Claudia Colangelo & Simona Ippoliti & Cristian Petre Ilie & Anne Carrie & Nicola Veronese & Lee Smith, 2021. "Laparoscopy in Low-Income Countries: 10-Year Experience and Systematic Literature Review," IJERPH, MDPI, vol. 18(11), pages 1-11, May.
    4. Alessandro Margherita & Emanuele Banchi & Alfredo Biffi & Gianluca di Castri & Rocco Morelli, 2022. "Beyond Total Cost Management (TCM) to Systemic Value Management (SVM): Transformational Trends and a Research Manifesto for an Evolving Discipline," Sustainability, MDPI, vol. 14(19), pages 1-16, October.
    5. Fabio Magnacca & Riccardo Giannetti, 2024. "Management accounting and new product development: a systematic literature review and future research directions," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 28(2), pages 651-685, June.
    6. Evans, Rhiannon & White, James & Turley, Ruth & Slater, Thomas & Morgan, Helen & Strange, Heather & Scourfield, Jonathan, 2017. "Comparison of suicidal ideation, suicide attempt and suicide in children and young people in care and non-care populations: Systematic review and meta-analysis of prevalence," Children and Youth Services Review, Elsevier, vol. 82(C), pages 122-129.
    7. Hang-Nga Mai & Jaeil Kim & Youn-Hee Choi & Du-Hyeong Lee, 2020. "Accuracy of Portable Face-Scanning Devices for Obtaining Three-Dimensional Face Models: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(1), pages 1-15, December.
    8. D. L. I. H. K. Peiris & Yanping Duan & Corneel Vandelanotte & Wei Liang & Min Yang & Julien Steven Baker, 2022. "Effects of In-Classroom Physical Activity Breaks on Children’s Academic Performance, Cognition, Health Behaviours and Health Outcomes: A Systematic Review and Meta-Analysis of Randomised Controlled Tr," IJERPH, MDPI, vol. 19(15), pages 1-27, August.
    9. Stephanie Kovacs & Stephen E Hawes & Stephen N Maley & Emily Mosites & Ling Wong & Andy Stergachis, 2014. "Technologies for Detecting Falsified and Substandard Drugs in Low and Middle-Income Countries," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-11, March.
    10. Najmiatul Fitria & Antoinette D. I. Asselt & Maarten J. Postma, 2019. "Cost-effectiveness of controlling gestational diabetes mellitus: a systematic review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(3), pages 407-417, April.
    11. Hyun Woo Lee & Jung Kyu Lee & Eunyoung Kim & Jae-Joon Yim & Chang-Hoon Lee, 2016. "The Effectiveness and Safety of Fluoroquinolone-Containing Regimen as a First-Line Treatment for Drug-Sensitive Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-15, July.
    12. Jung Soo Kim & Jinkyeong Park & Seong Yong Lim & Yeon-Mok Oh & Kwang Ha Yoo & Yong Bum Park & Seung Soo Sheen & Min-Ji Kim & K C Carriere & Ji Ye Jung & Hye Yun Park, 2015. "Comparison of Clinical Efficacy and Safety between Indacaterol and Tiotropium in COPD: Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-12, March.
    13. Giuseppe La Torre & Remigio Bova & Rosario Andrea Cocchiara & Cristina Sestili & Anna Tagliaferri & Simona Maggiacomo & Camilla Foschi & William Zomparelli & Maria Vittoria Manai & David Shaholli & Va, 2023. "What Are the Determinants of the Quality of Systematic Reviews in the International Journals of Occupational Medicine? A Methodological Study Review of Published Literature," IJERPH, MDPI, vol. 20(2), pages 1-12, January.
    14. Eric P F Chow & Joseph D Tucker & Frank Y Wong & Eric J Nehl & Yanjie Wang & Xun Zhuang & Lei Zhang, 2014. "Disparities and Risks of Sexually Transmissible Infections among Men Who Have Sex with Men in China: A Meta-Analysis and Data Synthesis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-13, February.
    15. Ricky D Turgeon & Michael R Kolber & Peter Loewen & Ursula Ellis & James P McCormack, 2019. "Higher versus lower doses of ACE inhibitors, angiotensin-2 receptor blockers and beta-blockers in heart failure with reduced ejection fraction: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-18, February.
    16. Adrián Csordás & Péter Lengyel & István Füzesi, 2022. "Who Prefers Regional Products? A Systematic Literature Review of Consumer Characteristics and Attitudes in Short Food Supply Chains," Sustainability, MDPI, vol. 14(15), pages 1-17, July.
    17. Zheng Yuan & Baohua Wen & Cheng He & Jin Zhou & Zhonghua Zhou & Feng Xu, 2022. "Application of Multi-Criteria Decision-Making Analysis to Rural Spatial Sustainability Evaluation: A Systematic Review," IJERPH, MDPI, vol. 19(11), pages 1-31, May.
    18. Bertha Leticia Treviño-Elizondo & Heriberto García-Reyes & Rodrigo E. Peimbert-García, 2023. "A Maturity Model to Become a Smart Organization Based on Lean and Industry 4.0 Synergy," Sustainability, MDPI, vol. 15(17), pages 1-24, September.
    19. Zhenjie Wu & Yunjiu Cheng & Lynn Htet Htet Aung & Bixun Li, 2013. "Association between Adiponectin Concentrations and Cardiovascular Disease in Diabetic Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-6, November.
    20. Moe Soheilian & Géza Fischl & Myriam Aries, 2021. "Smart Lighting Application for Energy Saving and User Well-Being in the Residential Environment," Sustainability, MDPI, vol. 13(11), pages 1-17, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pntd00:0008383. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosntds (email available below). General contact details of provider: https://journals.plos.org/plosntds/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.