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Brain-Derived Neurotrophic Factor and Antidepressive Effect of Electroconvulsive Therapy: Systematic Review and Meta-Analyses of the Preclinical and Clinical Literature

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  • M Polyakova
  • M L Schroeter
  • B M Elzinga
  • S Holiga
  • P Schoenknecht
  • E R de Kloet
  • M L Molendijk

Abstract

Emerging data suggest that Electro-Convulsive Treatment (ECT) may reduce depressive symptoms by increasing the expression of Brain-Derived Neurotrophic Factor (BDNF). Yet, conflicting findings have been reported. For this reason we performed a systematic review and meta-analysis of the preclinical and clinical literature on the association between ECT treatment (ECS in animals) and changes in BDNF concentrations and their effect on behavior. In addition, regional brain expression of BDNF in mouse and human brains were compared using Allen Brain Atlas. ECS, over sham, increased BDNF mRNA and protein in animal brain (effect size [Hedge’s g]: 0.38―0.54; 258 effect-size estimates, N = 4,284) but not in serum (g = 0.06, 95% CI = -0.05―0.17). In humans, plasma but not serum BDNF increased following ECT (g = 0.72 vs. g = 0.14; 23 effect sizes, n = 281). The gradient of the BDNF increment in animal brains corresponded to the gradient of the BDNF gene expression according to the Allen brain atlas. Effect-size estimates were larger following more ECT sessions in animals (r = 0.37, P

Suggested Citation

  • M Polyakova & M L Schroeter & B M Elzinga & S Holiga & P Schoenknecht & E R de Kloet & M L Molendijk, 2015. "Brain-Derived Neurotrophic Factor and Antidepressive Effect of Electroconvulsive Therapy: Systematic Review and Meta-Analyses of the Preclinical and Clinical Literature," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-18, November.
    • Handle: RePEc:plo:pone00:0141564
    DOI: 10.1371/journal.pone.0141564
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Carol Kilkenny & William J Browne & Innes C Cuthill & Michael Emerson & Douglas G Altman, 2010. "Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research," PLOS Biology, Public Library of Science, vol. 8(6), pages 1-5, June.
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    1. Chanjuan Zhou & Jiaju Zhong & Bin Zou & Liang Fang & Jianjun Chen & Xiao Deng & Lin Zhang & Xiang Zhao & Zehui Qu & Yang Lei & Ting Lei, 2017. "Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-18, February.

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