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Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy

Author

Listed:
  • Audrey C. Luo

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Valerie J. Sydnor

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Adam Pines

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    Stanford University)

  • Bart Larsen

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    University of Minnesota)

  • Aaron F. Alexander-Bloch

    (University of Pennsylvania
    University of Pennsylvania
    Children’s Hospital of Philadelphia)

  • Matthew Cieslak

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Sydney Covitz

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Andrew A. Chen

    (Medical University of South Carolina)

  • Nathalia Bianchini Esper

    (Child Mind Institute)

  • Eric Feczko

    (Child Mind Institute)

  • Alexandre R. Franco

    (Child Mind Institute
    Nathan Kline Institute for Psychiatric Research
    NYU Grossman School of Medicine)

  • Raquel E. Gur

    (University of Pennsylvania
    University of Pennsylvania
    Children’s Hospital of Philadelphia)

  • Ruben C. Gur

    (University of Pennsylvania
    University of Pennsylvania)

  • Audrey Houghton

    (University of Minnesota)

  • Fengling Hu

    (University of Pennsylvania
    University of Pennsylvania)

  • Arielle S. Keller

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Gregory Kiar

    (Child Mind Institute)

  • Kahini Mehta

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Giovanni A. Salum

    (Child Mind Institute
    Universidade Federal do Rio Grande do Sul)

  • Tinashe Tapera

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    Northeastern University)

  • Ting Xu

    (Child Mind Institute)

  • Chenying Zhao

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Taylor Salo

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Damien A. Fair

    (University of Minnesota
    University of Minnesota Medical School
    University of Minnesota)

  • Russell T. Shinohara

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Michael P. Milham

    (Child Mind Institute
    Nathan Kline Institute for Psychiatric Research)

  • Theodore D. Satterthwaite

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

Abstract

Human cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices to transmodal association cortices. Here, we investigate the hypothesis that the development of functional connectivity during childhood through adolescence conforms to the cortical hierarchy defined by the sensorimotor-association axis. We tested this pre-registered hypothesis in four large-scale, independent datasets (total n = 3355; ages 5–23 years): the Philadelphia Neurodevelopmental Cohort (n = 1207), Nathan Kline Institute-Rockland Sample (n = 397), Human Connectome Project: Development (n = 625), and Healthy Brain Network (n = 1126). Across datasets, the development of functional connectivity systematically varied along the sensorimotor-association axis. Connectivity in sensorimotor regions increased, whereas connectivity in association cortices declined, refining and reinforcing the cortical hierarchy. These consistent and generalizable results establish that the sensorimotor-association axis of cortical organization encodes the dominant pattern of functional connectivity development.

Suggested Citation

  • Audrey C. Luo & Valerie J. Sydnor & Adam Pines & Bart Larsen & Aaron F. Alexander-Bloch & Matthew Cieslak & Sydney Covitz & Andrew A. Chen & Nathalia Bianchini Esper & Eric Feczko & Alexandre R. Franc, 2024. "Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47748-w
    DOI: 10.1038/s41467-024-47748-w
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    References listed on IDEAS

    as
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