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Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections

Author

Listed:
  • Gustavo Balbinot

    (Toronto Rehabilitation Institute, University Health Network
    University Health Network
    University Health Network)

  • Guijin Li

    (Toronto Rehabilitation Institute, University Health Network
    Institute of Biomedical Engineering, University of Toronto)

  • Sukhvinder Kalsi-Ryan

    (Toronto Rehabilitation Institute, University Health Network
    University of Toronto
    University of Toronto)

  • Rainer Abel

    (Hohe Warte Bayreuth)

  • Doris Maier

    (BG-Trauma Center)

  • Yorck-Bernhard Kalke

    (RKU Universitäts- und Rehabilitationskliniken Ulm)

  • Norbert Weidner

    (Heidelberg University Hospital)

  • Rüdiger Rupp

    (Heidelberg University Hospital)

  • Martin Schubert

    (Balgrist University Hospital)

  • Armin Curt

    (Balgrist University Hospital)

  • Jose Zariffa

    (Toronto Rehabilitation Institute, University Health Network
    Institute of Biomedical Engineering, University of Toronto
    University of Toronto
    University of Toronto)

Abstract

Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may include dextrous hand function. Although prior work has focused on the recovery at the person-level, the factors determining the recovery of individual muscles are poorly understood. Here, we investigate the muscle-specific recovery after cervical spinal cord injury in a retrospective analysis of 748 individuals from the European Multicenter Study about Spinal Cord Injury (NCT01571531). We show associations between corticospinal tract (CST) sparing and upper extremity recovery in SCI, which improves the prediction of hand muscle strength recovery. Our findings suggest that assessment strategies for muscle-specific motor recovery in acute spinal cord injury are improved by accounting for CST sparing, and complement person-level predictions.

Suggested Citation

  • Gustavo Balbinot & Guijin Li & Sukhvinder Kalsi-Ryan & Rainer Abel & Doris Maier & Yorck-Bernhard Kalke & Norbert Weidner & Rüdiger Rupp & Martin Schubert & Armin Curt & Jose Zariffa, 2023. "Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36390-7
    DOI: 10.1038/s41467-023-36390-7
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