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Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Author

Listed:
  • Tengyue Jian

    (Pacific Northwest National Laboratory)

  • Yicheng Zhou

    (Pacific Northwest National Laboratory
    Washington State University)

  • Peipei Wang

    (Washington State University)

  • Wenchao Yang

    (Pacific Northwest National Laboratory
    Tianjin University)

  • Peng Mu

    (Pacific Northwest National Laboratory
    State University of New York)

  • Xin Zhang

    (Pacific Northwest National Laboratory)

  • Xiao Zhang

    (Washington State University)

  • Chun-Long Chen

    (Pacific Northwest National Laboratory
    University of Washington)

Abstract

Developing tunable and stable peroxidase mimetics with high catalytic efficiency provides a promising opportunity to improve and expand enzymatic catalysis in lignin depolymerization. A class of peptoid-based peroxidase mimetics with tunable catalytic activity and high stability is developed by constructing peptoids and hemins into self-assembled crystalline nanomaterials. By varying peptoid side chain chemistry to tailor the microenvironment of active sites, these self-assembled peptoid/hemin nanomaterials (Pep/hemin) exhibit highly modulable catalytic activities toward two lignin model substrates 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 3,3’,5,5’-tetramethylbenzidine. Among them, a Pep/hemin complex containing the pyridyl side chain showed the best catalytic efficiency (Vmax/Km = 5.81 × 10−3 s−1). These Pep/hemin catalysts are highly stable; kinetics studies suggest that they follow a peroxidase-like mechanism. Moreover, they exhibit a high efficacy on depolymerization of a biorefinery lignin. Because Pep/hemin catalysts are highly robust and tunable, we expect that they offer tremendous opportunities for lignin valorization to high value products.

Suggested Citation

  • Tengyue Jian & Yicheng Zhou & Peipei Wang & Wenchao Yang & Peng Mu & Xin Zhang & Xiao Zhang & Chun-Long Chen, 2022. "Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30285-9
    DOI: 10.1038/s41467-022-30285-9
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    References listed on IDEAS

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    1. Haibao Jin & Yan-Huai Ding & Mingming Wang & Yang Song & Zhihao Liao & Christina J. Newcomb & Xuepeng Wu & Xian-Qiong Tang & Zheng Li & Yuehe Lin & Feng Yan & Tengyue Jian & Peng Mu & Chun-Long Chen, 2018. "Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    2. Cheng, Feng & Brewer, Catherine E., 2017. "Producing jet fuel from biomass lignin: Potential pathways to alkyl-benzenes and cycloalkanes," Renewable and Sustainable Energy Reviews, Elsevier, vol. 72(C), pages 673-722.
    3. Haibao Jin & Fang Jiao & Michael D. Daily & Yulin Chen & Feng Yan & Yan-Huai Ding & Xin Zhang & Ellen J. Robertson & Marcel D. Baer & Chun-Long Chen, 2016. "Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids," Nature Communications, Nature, vol. 7(1), pages 1-8, November.
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