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Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids

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  • Haibao Jin

    (Pacific Northwest National Laboratory)

  • Fang Jiao

    (Pacific Northwest National Laboratory
    School of Chemistry and Molecular Engineering, East China Normal University)

  • Michael D. Daily

    (Pacific Northwest National Laboratory
    Present address: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA.)

  • Yulin Chen

    (Pacific Northwest National Laboratory)

  • Feng Yan

    (Pacific Northwest National Laboratory
    College of Chemistry and Chemical Engineering, Linyi University)

  • Yan-Huai Ding

    (Pacific Northwest National Laboratory
    Institute of Rheology Mechanics, Xiangtan University)

  • Xin Zhang

    (Pacific Northwest National Laboratory)

  • Ellen J. Robertson

    (Molecular Foundry, Lawrence Berkeley National Laboratory)

  • Marcel D. Baer

    (Pacific Northwest National Laboratory)

  • Chun-Long Chen

    (Pacific Northwest National Laboratory)

Abstract

An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. We further demonstrated the use of peptoid membranes as a robust platform to incorporate and pattern functional objects through large side-chain diversity and/or co-crystallization approaches. Similar to lipid membranes, peptoid membranes exhibit changes in thickness upon exposure to external stimuli; they can coat surfaces in single layers and self-repair. We anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix for development of biomimetic membranes tailored to specific applications.

Suggested Citation

  • Haibao Jin & Fang Jiao & Michael D. Daily & Yulin Chen & Feng Yan & Yan-Huai Ding & Xin Zhang & Ellen J. Robertson & Marcel D. Baer & Chun-Long Chen, 2016. "Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids," Nature Communications, Nature, vol. 7(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12252
    DOI: 10.1038/ncomms12252
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    Cited by:

    1. Tengyue Jian & Yicheng Zhou & Peipei Wang & Wenchao Yang & Peng Mu & Xin Zhang & Xiao Zhang & Chun-Long Chen, 2022. "Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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