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Assembled peptoid crystalline nanomaterials as carbonic anhydrase mimics for promoted hydration and sequestration of CO2

Author

Listed:
  • Progyateg Chakma

    (Pacific Northwest National Laboratory)

  • Ying Chen

    (Pacific Northwest National Laboratory)

  • Bradley S. Harris

    (Pacific Northwest National Laboratory)

  • Yasmene W. Elhady

    (Pacific Northwest National Laboratory
    University of Washington)

  • Renyu Zheng

    (Pacific Northwest National Laboratory
    University of Washington)

  • Mark E. Bowden

    (Pacific Northwest National Laboratory)

  • Vaithiyalingam Shutthanandan

    (Pacific Northwest National Laboratory)

  • Alexander B. Bard

    (Pacific Northwest National Laboratory)

  • Thi Kim Hoang Trinh

    (Pacific Northwest National Laboratory)

  • Xueyun Zheng

    (Pacific Northwest National Laboratory)

  • Christopher J. Mundy

    (Pacific Northwest National Laboratory
    University of Washington)

  • Marcel D. Baer

    (Pacific Northwest National Laboratory)

  • Chun-Long Chen

    (Pacific Northwest National Laboratory
    University of Washington)

Abstract

Carbonic anhydrase (CA) mimics have received significant attention due to their promising applications in the enhanced hydration and sequestration of CO2. Herein, we report the assembly of sequence-defined peptoids into crystalline nanomaterials with controlled microenvironment of active sites as CA mimics for promoted hydration and sequestration of CO2. By incorporating specific ligands into self-assembling peptoids and coordinating these ligands with metal cations, we synthesize a variety of crystalline nanosheets and nanotubes as efficient CA mimics comparable to natural bovine CA. Molecular dynamics simulations reveal the critical roles of peptoid-Zn2+ binding energy and the active site local microenvironment on the catalytic performance of these CA mimics. CO2 precipitation results show that these CA mimics promote the hydration and sequestration of CO2 while retaining high thermal and chemical stabilities. This study offers essential guidance for the future design of high-performance CA-mimics suitable for applications in CO2 capture and sequestration.

Suggested Citation

  • Progyateg Chakma & Ying Chen & Bradley S. Harris & Yasmene W. Elhady & Renyu Zheng & Mark E. Bowden & Vaithiyalingam Shutthanandan & Alexander B. Bard & Thi Kim Hoang Trinh & Xueyun Zheng & Christophe, 2025. "Assembled peptoid crystalline nanomaterials as carbonic anhydrase mimics for promoted hydration and sequestration of CO2," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62366-w
    DOI: 10.1038/s41467-025-62366-w
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    References listed on IDEAS

    as
    1. Jin Kyun Kim & Cheol Lee & Seon Woo Lim & Aniruddha Adhikari & Jacob T. Andring & Robert McKenna & Cheol-Min Ghim & Chae Un Kim, 2020. "Elucidating the role of metal ions in carbonic anhydrase catalysis," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. Haibao Jin & Fang Jiao & Michael D. Daily & Yulin Chen & Feng Yan & Yan-Huai Ding & Xin Zhang & Ellen J. Robertson & Marcel D. Baer & Chun-Long Chen, 2016. "Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids," Nature Communications, Nature, vol. 7(1), pages 1-8, November.
    3. Yan Xu & Liang Feng & Philip D. Jeffrey & Yigong Shi & François M. M. Morel, 2008. "Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms," Nature, Nature, vol. 452(7183), pages 56-61, March.
    4. Tengyue Jian & Yicheng Zhou & Peipei Wang & Wenchao Yang & Peng Mu & Xin Zhang & Xiao Zhang & Chun-Long Chen, 2022. "Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Ranjan V. Mannige & Thomas K. Haxton & Caroline Proulx & Ellen J. Robertson & Alessia Battigelli & Glenn L. Butterfoss & Ronald N. Zuckermann & Stephen Whitelam, 2015. "Peptoid nanosheets exhibit a new secondary-structure motif," Nature, Nature, vol. 526(7573), pages 415-420, October.
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