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Serum metabolome associated with severity of acute traumatic brain injury

Author

Listed:
  • Ilias Thomas

    (Örebro University)

  • Alex M. Dickens

    (University of Turku and Åbo Akademi University
    University of Turku)

  • Jussi P. Posti

    (Turku University Hospital and University of Turku)

  • Endre Czeiter

    (University of Pécs
    University of Pécs
    MTA-PTE Clinical Neuroscience MR Research Group)

  • Daniel Duberg

    (Örebro University)

  • Tim Sinioja

    (Örebro University)

  • Matilda Kråkström

    (University of Turku and Åbo Akademi University)

  • Isabel R. A. Retel Helmrich

    (Erasmus MC-University Medical Center)

  • Kevin K. W. Wang

    (McKnight Brin Institute of the University of Florida)

  • Andrew I. R. Maas

    (Antwerp University Hospital and University of Antwerp)

  • Ewout W. Steyerberg

    (Erasmus MC-University Medical Center
    Leiden University Medical Center)

  • David K. Menon

    (University of Cambridge, Addenbrooke’s Hospital)

  • Olli Tenovuo

    (Turku University Hospital and University of Turku)

  • Tuulia Hyötyläinen

    (Örebro University)

  • András Büki

    (Örebro University
    University of Pécs
    University of Pécs)

  • Matej Orešič

    (Örebro University
    University of Turku and Åbo Akademi University)

Abstract

Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.

Suggested Citation

  • Ilias Thomas & Alex M. Dickens & Jussi P. Posti & Endre Czeiter & Daniel Duberg & Tim Sinioja & Matilda Kråkström & Isabel R. A. Retel Helmrich & Kevin K. W. Wang & Andrew I. R. Maas & Ewout W. Steyer, 2022. "Serum metabolome associated with severity of acute traumatic brain injury," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30227-5
    DOI: 10.1038/s41467-022-30227-5
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    References listed on IDEAS

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