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Structural snapshots of human pre-60S ribosomal particles before and after nuclear export

Author

Listed:
  • Xiaomeng Liang

    (Tsinghua University
    Peking University)

  • Mei-Qing Zuo

    (China Agricultural University
    National Institute of Biological Sciences
    Tsinghua University)

  • Yunyang Zhang

    (Peking University)

  • Ningning Li

    (Peking University)

  • Chengying Ma

    (Peking University)

  • Meng-Qiu Dong

    (National Institute of Biological Sciences
    Tsinghua University)

  • Ning Gao

    (Peking University)

Abstract

Ribosome biogenesis is an elaborate and energetically expensive program that involve two hundred protein factors in eukaryotes. Nuclear export of pre-ribosomal particles is one central step which also serves as an internal structural checkpoint to ensure the proper completion of nuclear assembly events. Here we present four structures of human pre-60S particles isolated through a nuclear export factor NMD3, representing assembly stages immediately before and after nuclear export. These structures reveal locations of a dozen of human factors, including an uncharacterized factor TMA16 localized between the 5S RNA and the P0 stalk. Comparison of these structures shows a progressive maturation for the functional regions, such as peptidyl transferase centre and peptide exit tunnel, and illustrate a sequence of factor-assisted rRNA maturation events. These data facilitate our understanding of the global conservation of ribosome assembly in eukaryotes and species-specific features of human assembly factors.

Suggested Citation

  • Xiaomeng Liang & Mei-Qing Zuo & Yunyang Zhang & Ningning Li & Chengying Ma & Meng-Qiu Dong & Ning Gao, 2020. "Structural snapshots of human pre-60S ribosomal particles before and after nuclear export," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17237-x
    DOI: 10.1038/s41467-020-17237-x
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    References listed on IDEAS

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    1. Rajagopal, 2014. "The Human Factors," Palgrave Macmillan Books, in: Architecting Enterprise, chapter 9, pages 225-249, Palgrave Macmillan.
    2. Michael Ameismeier & Jingdong Cheng & Otto Berninghausen & Roland Beckmann, 2018. "Visualizing late states of human 40S ribosomal subunit maturation," Nature, Nature, vol. 558(7709), pages 249-253, June.
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    Cited by:

    1. Sébastien Durand & Marion Bruelle & Fleur Bourdelais & Bigitha Bennychen & Juliana Blin-Gonthier & Caroline Isaac & Aurélia Huyghe & Sylvie Martel & Antoine Seyve & Christophe Vanbelle & Annie Adrait , 2023. "RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Kamil Sekulski & Victor Emmanuel Cruz & Christine S. Weirich & Jan P. Erzberger, 2023. "rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Jan Andreas Ruland & Annika Marie Krüger & Kerstin Dörner & Rohan Bhatia & Sabine Wirths & Daniel Poetes & Ulrike Kutay & Jan Peter Siebrasse & Ulrich Kubitscheck, 2021. "Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Matthias M. Zimmer & Anuja Kibe & Ulfert Rand & Lukas Pekarek & Liqing Ye & Stefan Buck & Redmond P. Smyth & Luka Cicin-Sain & Neva Caliskan, 2021. "The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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