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Preventive Metformin Monotherapy Medication Prescription, Redemption and Socioeconomic Status in Hungary in 2018–2019: A Cross-Sectional Study

Author

Listed:
  • Csilla Nagy

    (Public Health Administration Service of Government Office of Capital City Budapest, 1138 Budapest, Hungary)

  • Attila Juhász

    (Public Health Administration Service of Government Office of Capital City Budapest, 1138 Budapest, Hungary)

  • Péter Pikó

    (MTA-DE-Public Health Research Group, University of Debrecen, 4028 Debrecen, Hungary)

  • Judit Diószegi

    (MTA-DE-Public Health Research Group, University of Debrecen, 4028 Debrecen, Hungary)

  • György Paragh

    (Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary)

  • Zoltán Szabó

    (Department of Emergency Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary)

  • Orsolya Varga

    (Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary)

  • Róza Ádány

    (MTA-DE-Public Health Research Group, University of Debrecen, 4028 Debrecen, Hungary
    Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary)

Abstract

This study was designed to characterize the spatial distribution of metformin medication used as first-line monotherapy for prevention of T2DM in relationship with the socioeconomic status (level of deprivation) and T2DM mortality at district level in a nationwide cross-sectional ecological study for the first time in a European country, Hungary. Risk analysis was used to estimate the relationships between socioeconomic status, characterized by tertiles of deprivation index, and mortality caused by diabetes, and metformin medication (both prescription and redemption) for the years of 2018 and 2019 at the district level. The spatial distribution of districts with a higher relative frequency of metformin prescriptions and redemptions showed a positive correlation with socio-economic deprivation. Significant association between the relatively high T2DM mortality and the highest level of deprivation could also be detected, but less-deprived regions with high T2DM mortality and low metformin utilization could also be identified. Although the statistical associations detected in this ecological study do not indicate a causal relationship, it is reasonable to suppose that the underuse of metformin medication may contribute to the unfavourable T2DM mortality in certain regions. Our findings underline the need for more effective preventive services including metformin medication to decrease T2DM morbidity and mortality burden.

Suggested Citation

  • Csilla Nagy & Attila Juhász & Péter Pikó & Judit Diószegi & György Paragh & Zoltán Szabó & Orsolya Varga & Róza Ádány, 2021. "Preventive Metformin Monotherapy Medication Prescription, Redemption and Socioeconomic Status in Hungary in 2018–2019: A Cross-Sectional Study," IJERPH, MDPI, vol. 18(5), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2206-:d:504696
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    References listed on IDEAS

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    1. Róza Ádány & Péter Pikó & Szilvia Fiatal & Zsigmond Kósa & János Sándor & Éva Bíró & Karolina Kósa & György Paragh & Éva Bácsné Bába & Ilona Veres-Balajti & Klára Bíró & Orsolya Varga & Margit Balázs, 2020. "Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey," IJERPH, MDPI, vol. 17(13), pages 1-22, July.
    2. Julian Besag & Jeremy York & Annie Mollié, 1991. "Bayesian image restoration, with two applications in spatial statistics," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 43(1), pages 1-20, March.
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