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Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis

Author

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  • Hsiao-Ling Yang

    (School of Nursing, College of Medicine, National Taiwan University, Taipei 10051, Taiwan)

  • Ya-Ling Yang

    (School of Nursing, College of Medicine, National Taiwan University, Taipei 10051, Taiwan)

  • Chong Ho Yu

    (Department of Psychology, Azusa Pacific University, Azusa, CA 91702, USA)

  • S. Pamela K. Shiao

    (College of Nursing, Augusta University, Augusta, GA 30912, USA)

Abstract

Congenital heart disease (CHD) is the leading cause of death in children, and is affected by genetic and environmental factors. To investigate the association of air pollution with methylene-tetrahydrofolate reductase ( MTHFR ) polymorphisms and the risk of CHD, we included 58 study groups of children and parents, with 12,347 cases and 18,106 controls worldwide. Both MTHFR C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents. Countries with greater risks of CHD with a pooled risk ratio (RR) > 2 from MTHFR 677 polymorphisms included Germany, Portugal, China, and Egypt for children; and Brazil, Puerto Rico, Mexico, China, and Egypt for mothers. Whereas, countries with greater risk of CHD with RR > 2 from MTHFR 1298 polymorphisms included Taiwan, Turkey, and Egypt for children; and Brazil, China, and Egypt for mothers. Additionally, meta-prediction analysis revealed that the percentages of MTHFR 677TT and TT plus CT polymorphisms together were increased in countries with higher levels of air pollution, with a trend of increased CHD risks with higher levels of air pollution for children ( p = 0.07). Our findings may have significant implications for inflammatory pathways in association with MTHFR polymorphisms and future intervention studies to correct for folate-related enzyme deficits resulted from MTHFR polymorphisms to prevent CHDs for future generations.

Suggested Citation

  • Hsiao-Ling Yang & Ya-Ling Yang & Chong Ho Yu & S. Pamela K. Shiao, 2018. "Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis," IJERPH, MDPI, vol. 15(8), pages 1-18, August.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:8:p:1660-:d:162021
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    References listed on IDEAS

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    3. Ya-Ling Yang & Hsiao-Ling Yang & S. Pamela K. Shiao, 2018. "Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide," IJERPH, MDPI, vol. 15(2), pages 1-14, February.
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    6. Wei Wang & Yujia Wang & Fangqi Gong & Weihua Zhu & Songling Fu, 2013. "MTHFR C677T Polymorphism and Risk of Congenital Heart Defects: Evidence from 29 Case-Control and TDT Studies," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
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