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Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk

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  • Suh-Mian Wu

    (Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan
    Graduate Institute of Clinical Medical Sciences, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan)

  • Zhao-Feng Chen

    (Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan)

  • Lufei Young

    (College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA)

  • S. Pamela K. Shiao

    (College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA)

Abstract

Background : Alzheimer’s disease (AD) is a significant public health issue. AD has been linked with methylenetetrahydrofolate reductase ( MTHFR ) C677T polymorphism, but the findings have been inconsistent. The purpose of this meta-predictive analysis is to examine the associations between MTHFR polymorphisms and epigenetic factors, including air pollution, with AD risk using big data analytics approaches. Methods and Results : Forty-three studies (44 groups) were identified by searching various databases. MTHFR C677T TT and CT genotypes had significant associations with AD risk in all racial populations (RR = 1.13, p = 0.0047; and RR = 1.12, p < 0.0001 respectively). Meta-predictive analysis showed significant increases of percentages of MTHFR C677T polymorphism with increased air pollution levels in both AD case group and control group ( p = 0.0021–0.0457); with higher percentages of TT and CT genotypes in the AD case group than that in the control group with increased air pollution levels. Conclusions : The impact of MTHFR C677T polymorphism on susceptibility to AD was modified by level of air pollution. Future studies are needed to further examine the effects of gene-environment interactions including air pollution on AD risk for world populations.

Suggested Citation

  • Suh-Mian Wu & Zhao-Feng Chen & Lufei Young & S. Pamela K. Shiao, 2017. "Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk," IJERPH, MDPI, vol. 14(1), pages 1-14, January.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:1:p:63-:d:87487
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    1. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
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    Cited by:

    1. Hsiao-Ling Yang & Ya-Ling Yang & Chong Ho Yu & S. Pamela K. Shiao, 2018. "Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis," IJERPH, MDPI, vol. 15(8), pages 1-18, August.

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