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A Meta-Prediction of Methylenetetrahydrofolate-Reductase Polymorphisms and Air Pollution Increased the Risk of Ischemic Heart Diseases Worldwide

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  • Zhao-Feng Chen

    (Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan)

  • Lufei Young

    (College of Nursing, Augusta University, Augusta, GA 30912, USA)

  • Chong Ho Yu

    (Department of Psychology, Azusa Pacific University, Azusa, CA 91702, USA)

  • S. Pamela K. Shiao

    (College of Nursing, Augusta University, Augusta, GA 30912, USA)

Abstract

Ischemic heart disease (IHD) is among the leading causes of death worldwide. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been associated with IHD risk, but the findings presented with heterogeneity. The purpose of the present meta-analysis was to provide an updated evaluation by integrating machine-learning based analytics to examine the potential source of heterogeneity on the associations between MTHFR polymorphisms and the risk of various subtypes of IHD, as well as the possible impact of air pollution on MTHFR polymorphisms and IHD risks. A comprehensive search of various databases was conducted to locate 123 studies (29,697 cases and 31,028 controls) for MTHFR C677T, and 18 studies (7158 cases and 5482 controls) for MTHFR A1298C. Overall, MTHFR 677 polymorphisms were risks for IHD (TT: Risk ratio (RR) = 1.23, p < 0.0001; CT: RR = 1.04, p = 0.0028, and TT plus CT: RR = 1.09, p < 0.0001). In contrast, MTHFR 677 CC wildtype was protective against IHD (RR = 0.91, p < 0.00001) for overall populations. Three countries with elevated IHD risks from MTHFR C677T polymorphism with RR >2 included India, Turkey, and Tunisia. Meta-predictive analysis revealed that increased air pollution was associated with increased MTHFR 677 TT and CT polymorphisms in both the case and control group ( p < 0.05), with the trend of increased IHD risk resulting from increased air pollution. These results associate the potential inflammatory pathway with air pollution and the folate pathway with MTHFR polymorphism. Future intervention studies can be designed to mitigate MTHFR enzyme deficiencies resulting from gene polymorphisms to prevent IHDs for at-risk populations.

Suggested Citation

  • Zhao-Feng Chen & Lufei Young & Chong Ho Yu & S. Pamela K. Shiao, 2018. "A Meta-Prediction of Methylenetetrahydrofolate-Reductase Polymorphisms and Air Pollution Increased the Risk of Ischemic Heart Diseases Worldwide," IJERPH, MDPI, vol. 15(7), pages 1-16, July.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:7:p:1453-:d:157184
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    1. N. Speybroeck, 2012. "Classification and regression trees," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 57(1), pages 243-246, February.
    2. David S Wald & Joan K Morris & Nicholas J Wald, 2011. "Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-7, February.
    3. Gurdeep S Sagoo & Julian Little & Julian P T Higgins, 2009. "Systematic Reviews of Genetic Association Studies," PLOS Medicine, Public Library of Science, vol. 6(3), pages 1-7, March.
    4. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    5. Paul Bentley & George Peck & Liam Smeeth & John Whittaker & Pankaj Sharma, 2010. "Causal Relationship of Susceptibility Genes to Ischemic Stroke: Comparison to Ischemic Heart Disease and Biochemical Determinants," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-15, February.
    6. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    7. Ya-Ling Yang & Hsiao-Ling Yang & S. Pamela K. Shiao, 2018. "Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide," IJERPH, MDPI, vol. 15(2), pages 1-14, February.
    8. Sunaina Yadav & Nazeeha Hasan & Thomas Marjot & Muhammad S Khan & Kameshwar Prasad & Paul Bentley & Pankaj Sharma, 2013. "Detailed Analysis of Gene Polymorphisms Associated with Ischemic Stroke in South Asians," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
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