Survival estimation and testing via multiple imputation
Multiple imputation is a technique for handling data sets with missing values. The method fills in each missing value several times, creating many augmented data sets. Each augmented data set is analyzed separately and the results combined to give a final result consisting of an estimate and a measure of uncertainty. In this paper we consider nonparametric multiple-imputation methods to handle missing event times for censored observations in the context of nonparametric survival estimation and testing. Two nonparametric imputation schemes are considered. In risk set imputation the censored time is replaced by a random draw of the observed times amongst those at risk after the censoring time. In Kaplan-Meier (KM) imputation the imputed time is a draw from the estimated distribution of event times amongst those at risk after the censoring time. We show that with a large number of imputes the estimates from both methods reproduce the KM estimator. In a simulation study we show that the inclusion of a bootstrap stage in the multiple imputation algorithm gives coverage rates of confidence intervals that are comparable to that from Greenwood's formula. Connections to the redistribute to the right algorithm are discussed.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 58 (2002)
Issue (Month): 3 (July)
|Contact details of provider:|| Web page: http://www.elsevier.com/wps/find/journaldescription.cws_home/622892/description#description|
|Order Information:|| Postal: http://www.elsevier.com/wps/find/supportfaq.cws_home/regional|
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Schenker, Nathaniel & Taylor, Jeremy M. G., 1996. "Partially parametric techniques for multiple imputation," Computational Statistics & Data Analysis, Elsevier, vol. 22(4), pages 425-446, August.
When requesting a correction, please mention this item's handle: RePEc:eee:stapro:v:58:y:2002:i:3:p:221-232. See general information about how to correct material in RePEc.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Shamier, Wendy)
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If references are entirely missing, you can add them using this form.
If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.
Please note that corrections may take a couple of weeks to filter through the various RePEc services.