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A Bayesian Nonparametric Method for Prediction in EST Analysis


  • Antonio Lijoi


  • Ramsés H. Mena


  • Igor Prünster



In this work we propose a Bayesian nonparametric approach for tackling statistical problems related to EST surveys. In particular, we provide estimates for: a) the coverage, defined as the proportion of unique genes in the library represented in the given sample of reads; b) the number of new unique genes to be observed in a future sample; c) the discovery rate of new genes as a function of the future sample size. The Bayesian nonparametric model we adopt conveys, in a statistically rigorous way, the available information into prediction. Our proposal has appealing properties over frequentist nonparametric methods, which become unstable when prediction is required for large future samples. EST libraries studied in Susko and Roger (2004), with frequentist methods, are analyzed in detail.

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  • Antonio Lijoi & Ramsés H. Mena & Igor Prünster, 2007. "A Bayesian Nonparametric Method for Prediction in EST Analysis," ICER Working Papers - Applied Mathematics Series 16-2007, ICER - International Centre for Economic Research.
  • Handle: RePEc:icr:wpmath:16-2007

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    References listed on IDEAS

    1. Antonio Lijoi & Ramsés H. Mena & Igor Prünster, 2007. "Bayesian Nonparametric Estimation of the Probability of Discovering New Species," Biometrika, Biometrika Trust, vol. 94(4), pages 769-786.
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    Cited by:

    1. Stefano Favaro & Antonio Lijoi & Igor Prünster, 2012. "A New Estimator of the Discovery Probability," Biometrics, The International Biometric Society, vol. 68(4), pages 1188-1196, December.
    2. Cesari, Oriana & Favaro, Stefano & Nipoti, Bernardo, 2014. "Posterior analysis of rare variants in Gibbs-type species sampling models," Journal of Multivariate Analysis, Elsevier, vol. 131(C), pages 79-98.
    3. Zhang, Hongmei & Ghosh, Kaushik & Ghosh, Pulak, 2012. "Sampling designs via a multivariate hypergeometric-Dirichlet process model for a multi-species assemblage with unknown heterogeneity," Computational Statistics & Data Analysis, Elsevier, vol. 56(8), pages 2562-2573.
    4. Pierpaolo De Blasi & Stefano Favaro & Antonio Lijoi & Ramsés H. Mena & Igor Prünster & Mattteo Ruggiero, 2013. "Are Gibbs-type priors the most natural generalization of the Dirichlet process?," DEM Working Papers Series 054, University of Pavia, Department of Economics and Management.
    5. Stefano Favaro & Antonio Lijoi & Igor Prünster, 2012. "A new estimator of the discovery probability," DEM Working Papers Series 007, University of Pavia, Department of Economics and Management.
    6. Stefano Favaro & Antonio Lijoi & Ramsés H. Mena & Igor Prünster, 2009. "Bayesian non-parametric inference for species variety with a two-parameter Poisson-Dirichlet process prior," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 71(5), pages 993-1008.

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