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Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches

Author

Listed:
  • Dyfrig Hughes

    (Ardudwy, Bangor University)

  • Joanna Charles

    (Ardudwy, Bangor University)

  • Dalia Dawoud

    (Cairo University)

  • Rhiannon Tudor Edwards

    (Ardudwy, Bangor University)

  • Emily Holmes

    (Ardudwy, Bangor University)

  • Carys Jones

    (Ardudwy, Bangor University)

  • Paul Parham

    (University of Liverpool)

  • Catrin Plumpton

    (Ardudwy, Bangor University)

  • Colin Ridyard

    (Ardudwy, Bangor University)

  • Huw Lloyd-Williams

    (Ardudwy, Bangor University)

  • Eifiona Wood

    (Ardudwy, Bangor University)

  • Seow Tien Yeo

    (Ardudwy, Bangor University)

Abstract

Trial-based economic evaluations are an important aspect of health technology assessment. The availability of patient-level data coupled with unbiased estimates of clinical outcomes means that randomised controlled trials are effective vehicles for the generation of economic data. However there are methodological challenges to trial-based evaluations, including the collection of reliable data on resource use and cost, choice of health outcome measure, calculating minimally important differences, dealing with missing data, extrapolating outcomes and costs over time and the analysis of multinational trials. This review focuses on the state of the art of selective elements regarding the design, conduct, analysis and reporting of trial-based economic evaluations. The limitations of existing approaches are detailed and novel methods introduced. The review is internationally relevant but with a focus towards practice in the UK.

Suggested Citation

  • Dyfrig Hughes & Joanna Charles & Dalia Dawoud & Rhiannon Tudor Edwards & Emily Holmes & Carys Jones & Paul Parham & Catrin Plumpton & Colin Ridyard & Huw Lloyd-Williams & Eifiona Wood & Seow Tien Yeo, 2016. "Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches," PharmacoEconomics, Springer, vol. 34(5), pages 447-461, May.
    • Handle: RePEc:spr:pharme:v:34:y:2016:i:5:d:10.1007_s40273-015-0371-y
    DOI: 10.1007/s40273-015-0371-y
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    References listed on IDEAS

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    1. Don Husereau & Michael Drummond & Stavros Petrou & Chris Carswell & David Moher & Dan Greenberg & Federico Augustovski & Andrew Briggs & Josephine Mauskopf & Elizabeth Loder, 2013. "Consolidated Health Economic Evaluation Reporting Standards (CHEERS) Statement," PharmacoEconomics, Springer, vol. 31(5), pages 361-367, May.
    2. Clarke, Philip M. & Fiebig, Denzil G. & Gerdtham, Ulf-G., 2008. "Optimal recall length in survey design," Journal of Health Economics, Elsevier, vol. 27(5), pages 1275-1284, September.
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    4. Drummond, Michael F. & Sculpher, Mark J. & Torrance, George W. & O'Brien, Bernie J. & Stoddart, Greg L., 2005. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 3, number 9780198529453, Decembrie.
    5. Kenneth F Schulz & Douglas G Altman & David Moher & for the CONSORT Group, 2010. "CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-7, March.
    6. McPherson, C. J. & Addington-Hall, J. M., 2003. "Judging the quality of care at the end of life: can proxies provide reliable information?," Social Science & Medicine, Elsevier, vol. 56(1), pages 95-109, January.
    7. Weatherly, Helen & Drummond, Michael & Claxton, Karl & Cookson, Richard & Ferguson, Brian & Godfrey, Christine & Rice, Nigel & Sculpher, Mark & Sowden, Amanda, 2009. "Methods for assessing the cost-effectiveness of public health interventions: Key challenges and recommendations," Health Policy, Elsevier, vol. 93(2-3), pages 85-92, December.
    8. Glick, Henry A & Doshi, Jalpa A & Sonnad, Seema S & Polsky, Daniel, 2007. "Economic Evaluation in Clinical Trials," OUP Catalogue, Oxford University Press, number 9780198529972, Decembrie.
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    Cited by:

    1. Valentina Lorenzoni & Stefania Bellelli & Chiara Caselli & Juhani Knuuti & Stephen Richard Underwood & Danilo Neglia & Giuseppe Turchetti, 2019. "Cost-effectiveness analysis of stand-alone or combined non-invasive imaging tests for the diagnosis of stable coronary artery disease: results from the EVINCI study," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(9), pages 1437-1449, December.
    2. Alexina J. Mason & Manuel Gomes & Richard Grieve & James R. Carpenter, 2018. "A Bayesian framework for health economic evaluation in studies with missing data," Health Economics, John Wiley & Sons, Ltd., vol. 27(11), pages 1670-1683, November.
    3. Perraudin, Clémence & Bugnon, Olivier & Pelletier-Fleury, Nathalie, 2016. "Expanding professional pharmacy services in European community setting: Is it cost-effective? A systematic review for health policy considerations," Health Policy, Elsevier, vol. 120(12), pages 1350-1362.

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