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Seroprevalence and immunity of SARS-CoV-2 infection in children and adolescents in schools in Switzerland: design for a longitudinal, school-based prospective cohort study

Author

Listed:
  • Agne Ulyte

    (University of Zurich)

  • Thomas Radtke

    (University of Zurich)

  • Irène A. Abela

    (University of Zurich)

  • Sarah R. Haile

    (University of Zurich)

  • Julia Braun

    (University of Zurich)

  • Ruedi Jung

    (University of Zurich)

  • Christoph Berger

    (University Children’s Hospital Zurich)

  • Alexandra Trkola

    (University of Zurich)

  • Jan Fehr

    (University of Zurich)

  • Milo A. Puhan

    (University of Zurich)

  • Susi Kriemler

    (University of Zurich)

Abstract

Objectives This longitudinal cohort study aims to assess the extent and patterns of seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in school-attending children, and their parents and school personnel. It will examine risk factors for infection, the relationship between seropositivity and symptoms, and temporal persistence of antibodies. Methods The study (Ciao Corona) will enroll a regionally representative, random sample of schools in the canton of Zurich, where 18% of the Swiss population live. Children aged 5–16 years, attending primary and secondary schools, and their parents and school personnel are invited. Venous blood and saliva samples are collected for serological testing in June/July 2020, in October/November 2020, and in March/April 2021. Bi-monthly questionnaires will cover SARS-CoV-2 symptoms and tests, health, preventive behavior, and lifestyle information. Hierarchical Bayesian logistic regression models will account for sensitivity and specificity of the serological tests in the analyses and complex sampling structure, i.e., clustering within classes and schools. Results and conclusions This unique school-based study will allow describing temporal trends of immunity, evaluate effects of preventive measures and will inform goal-oriented policy decisions during subsequent outbreaks. Trial registration ClinicalTrials.gov Identifier: NCT04448717, registered June 26, 2020. https://clinicaltrials.gov/ct2/show/NCT04448717 .

Suggested Citation

  • Agne Ulyte & Thomas Radtke & Irène A. Abela & Sarah R. Haile & Julia Braun & Ruedi Jung & Christoph Berger & Alexandra Trkola & Jan Fehr & Milo A. Puhan & Susi Kriemler, 2020. "Seroprevalence and immunity of SARS-CoV-2 infection in children and adolescents in schools in Switzerland: design for a longitudinal, school-based prospective cohort study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 65(9), pages 1549-1557, December.
    • Handle: RePEc:spr:ijphth:v:65:y:2020:i:9:d:10.1007_s00038-020-01495-z
    DOI: 10.1007/s00038-020-01495-z
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    References listed on IDEAS

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    1. Joël Mossong & Niel Hens & Mark Jit & Philippe Beutels & Kari Auranen & Rafael Mikolajczyk & Marco Massari & Stefania Salmaso & Gianpaolo Scalia Tomba & Jacco Wallinga & Janneke Heijne & Malgorzata Sa, 2008. "Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases," PLOS Medicine, Public Library of Science, vol. 5(3), pages 1-1, March.
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    Cited by:

    1. Alessia Raineri & Thomas Radtke & Sonja Rueegg & Sarah R. Haile & Dominik Menges & Tala Ballouz & Agne Ulyte & Jan Fehr & Daniel L. Cornejo & Giuseppe Pantaleo & Céline Pellaton & Craig Fenwick & Milo, 2023. "Persistent humoral immune response in youth throughout the COVID-19 pandemic: prospective school-based cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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