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The effects of GLP-1 receptor agonists on visceral fat and liver ectopic fat in an adult population with or without diabetes and nonalcoholic fatty liver disease: A systematic review and meta-analysis

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  • Chao Liao
  • Xinyin Liang
  • Xiao Zhang
  • Yao Li

Abstract

Aim: To uncover the effect of GLP-1 receptor agonists (GLP-1 RAs) on the visceral- and hepatic fat content of adults. Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were searched from inception until November 2022. Randomized controlled trials (RCTs) of GLP-1Ras was extracted, including reports of effects on visceral adipose tissue and hepatic fat content in individuals with type 2 diabetes, non-type 2 diabetes, NAFLD (non-alcoholic fatty liver disease), and non-NAFLD. Meta-analyses used random-effects models. Results: 1736 individuals in the 30 qualified RCTs were included, comprising 1363 people with type 2 diabetes and 318 with NFLD. GLP-1 RAs reduced visceral adipose tissue (standard mean difference [SMD] = -0.59, 95% CI [-0.83, -0.36], P

Suggested Citation

  • Chao Liao & Xinyin Liang & Xiao Zhang & Yao Li, 2023. "The effects of GLP-1 receptor agonists on visceral fat and liver ectopic fat in an adult population with or without diabetes and nonalcoholic fatty liver disease: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(8), pages 1-20, August.
    • Handle: RePEc:plo:pone00:0289616
    DOI: 10.1371/journal.pone.0289616
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    1. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    2. Fupeng Liu & Qing Yang & Hongli Zhang & Yanhong Zhang & Guangzhi Yang & Bo Ban & Yanying Li & Mei Zhang, 2022. "The effects of glucagon-like peptide-1 receptor agonists on adipose tissues in patients with type 2 diabetes: A meta-analysis of randomised controlled trials," PLOS ONE, Public Library of Science, vol. 17(7), pages 1-13, July.
    3. Steven E. Kahn & Rebecca L. Hull & Kristina M. Utzschneider, 2006. "Mechanisms linking obesity to insulin resistance and type 2 diabetes," Nature, Nature, vol. 444(7121), pages 840-846, December.
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