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Mechanisms linking obesity to insulin resistance and type 2 diabetes

Author

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  • Steven E. Kahn

    (Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way)

  • Rebecca L. Hull

    (Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way)

  • Kristina M. Utzschneider

    (Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way)

Abstract

Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet β-cells — the cells that release insulin — failure to control blood glucose levels results. Abnormalities in β-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.

Suggested Citation

  • Steven E. Kahn & Rebecca L. Hull & Kristina M. Utzschneider, 2006. "Mechanisms linking obesity to insulin resistance and type 2 diabetes," Nature, Nature, vol. 444(7121), pages 840-846, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7121:d:10.1038_nature05482
    DOI: 10.1038/nature05482
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