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Determinant factors of leprosy-related disability; comparison of acceleration failure time and parametric shared frailty models

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  • Bezanesh Melese Masresha
  • Kasim Mohammed Yesuf
  • Yikeber Abebaw Moyehodie
  • Hailegebrael Birhan Biresaw
  • Solomon Sisay Mulugeta
  • Gedam Derbew Addisia

Abstract

Background: Leprosy is an illness persisting for a long time or constantly recurring brought about by Mycobacterium leprae. The collusion of the causing agent with Schwann cells leads to incapable of being changed loss of fringe nerve tissue; followed by incapacity and that is not restricted to actual powerlessness yet additionally makes a negative picture, prompting segregation and social disgrace against the altered people also, their families. Methods: The analysis of this study comprises 205 samples of patients at All African TB and Leprosy Rehabilitation and Training Centre from January 2015 up to December 2019 G.C who were taking medication for leprosy and who possess all necessary data. Territorial conditions in the region of the patients were utilized as a clustering impact in all frailty models. Acceleration failure time models and parametric shared frailty models with Weibull and log-strategic patterns were utilized to dissect hazard factors related to disability ensued by leprosy. All fitted models were looked at by utilizing AIC. Results: From that of 205, 69(33.7%) experienced at least one kind of disability grade during treatment taking. In light of AIC, log-logistic-gamma shared frailty model was the final best fitting model and also there was considerable variation among patients. The final model showed the age of patients, symptom duration, treatment category of patients, and sensory loss were found to be the most significant determinants of leprosy disability. Conclusion: In this investigation, there is proof of heterogeneity at the group level and disability was related to the age of patients, symptom duration, treatment category of patient, what’s more, sensory loss subsequently, uncommon consideration ought to be given to these huge indicators, which eventually diminish the event of disability. To lessen the patient-related postponement, the program should lay more noteworthy accentuation on bringing issues to light in the local area by zeroing in on key messages like indications, inability result of the late discovery, accessibility of free treatment what’s more, accessibility of disease care in general wellbeing office.

Suggested Citation

  • Bezanesh Melese Masresha & Kasim Mohammed Yesuf & Yikeber Abebaw Moyehodie & Hailegebrael Birhan Biresaw & Solomon Sisay Mulugeta & Gedam Derbew Addisia, 2023. "Determinant factors of leprosy-related disability; comparison of acceleration failure time and parametric shared frailty models," PLOS ONE, Public Library of Science, vol. 18(4), pages 1-26, April.
    • Handle: RePEc:plo:pone00:0271883
    DOI: 10.1371/journal.pone.0271883
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    References listed on IDEAS

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