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Efficacy and safety of Xuebijing injection for radiation pneumonitis: A meta-analysis

Author

Listed:
  • Zheng Li
  • Dandan Wang
  • Ying Zhang
  • Shuo Wang
  • Xueqian Wang
  • Yuxiao Li
  • Yuerong Gui
  • Jun Dong
  • Wei Hou

Abstract

Background: Currently, the treatment of radiation pneumonitis (RP) remains a clinical challenge. Although glucocorticoids are used for RP treatment, they have associated side effects. Xuebijing injection (XBJ) has been widely used for RP treatment in China, but so far no meta-analysis has evaluated its efficacy and safety. Methods: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, WANFANG database, SinoMED, and China Science and Technology J Database were searched for randomized controlled trials related to XBJ in RP treatment. Two researchers independently conducted literature screening, data extraction, and risk of bias assessment. The outcomes were synthesized and analyzed using the Cochrane Review Manager (RevMan 5.3) software, and a forest plot generated. Result: Eight articles met the eligibility criteria for further data extraction and meta-analysis. A total of 578 patients with RP participated in these studies, including 296 in the experimental group (XBJ+BT), and 282 in the control group (BT). The results of the meta-analysis revealed that compared to the BT group, XBJ+BT significantly increased the total effective rate (n = 578; RR = 1.45, 95% CI: 1.30 to 1.61, p

Suggested Citation

  • Zheng Li & Dandan Wang & Ying Zhang & Shuo Wang & Xueqian Wang & Yuxiao Li & Yuerong Gui & Jun Dong & Wei Hou, 2022. "Efficacy and safety of Xuebijing injection for radiation pneumonitis: A meta-analysis," PLOS ONE, Public Library of Science, vol. 17(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0268819
    DOI: 10.1371/journal.pone.0268819
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