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Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis

Author

Listed:
  • Alexandra Csenkey
  • Gergo Jozsa
  • Noemi Gede
  • Eszter Pakai
  • Benedek Tinusz
  • Zoltan Rumbus
  • Anita Lukacs
  • Zoltan Gyongyi
  • Peter Hamar
  • Robert Sepp
  • Andrej A Romanovsky
  • Peter Hegyi
  • Peter Vajda
  • Andras Garami

Abstract

In pediatric burns the use of systemic antibiotic prophylaxis is a standard procedure in some burn centers, though its beneficial effect on the infectious complications is debated. The present meta-analysis aimed at determining whether systemic antibiotic prophylaxis prevents infectious complications in pediatric patients with burn injuries. We searched the PubMed, EMBASE, and Cochrane Library databases from inception to August 2019. We included 6 studies, in which event rates of infectious complications were reported in children with burn injuries receiving or not receiving systemic antibiotic prophylaxis. We found that the overall odds ratio (OR) of developing an infection (including local and systemic) was not different between the groups (OR = 1.35; 95% CI, 0.44, 4.18). The chances for systemic infectious complications alone were also not different between antibiotic-treated and non-treated patients (OR = 0.74; 95% CI, 0.38, 1.45). Based on the age, affected total body surface area, and country income level, we did not find any subgroup that benefited from the prophylaxis. Our findings provide quantitative evidence for the inefficacy of systemic antibiotic prophylaxis in preventing infections in pediatric burns. To validate our conclusion, multinational, randomized trials in a diverse population of children with burn injuries are warranted.

Suggested Citation

  • Alexandra Csenkey & Gergo Jozsa & Noemi Gede & Eszter Pakai & Benedek Tinusz & Zoltan Rumbus & Anita Lukacs & Zoltan Gyongyi & Peter Hamar & Robert Sepp & Andrej A Romanovsky & Peter Hegyi & Peter Vaj, 2019. "Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0223063
    DOI: 10.1371/journal.pone.0223063
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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Zoltan Rumbus & Robert Matics & Peter Hegyi & Csaba Zsiboras & Imre Szabo & Anita Illes & Erika Petervari & Marta Balasko & Katalin Marta & Alexandra Miko & Andrea Parniczky & Judit Tenk & Ildiko Rost, 2017. "Fever Is Associated with Reduced, Hypothermia with Increased Mortality in Septic Patients: A Meta-Analysis of Clinical Trials," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.
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