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Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and meta-analysis

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  • Siying Tao
  • Yan Zhu
  • He Yuan
  • Sibei Tao
  • Yiming Cheng
  • Jiyao Li
  • Libang He

Abstract

The study aimed to evaluate the efficacy of the combination of CPP-ACP and fluorides compared with fluorides monotherapy on patients with early caries lesions. The Medline, Embase and Cochrane databases up to August 2017 were scanned, with no restrictions. Studies satisfied the guideline of randomised controlled trials (RCTs), the patients with early caries lesions and data considering the efficacy of fluorides and CPP-ACP versus fluorides alone were selected. There was no language restriction during the literature search process, however, only papers in English or Chinese were included during the selection process. Outcome variables include laser fluorescence, quantitative light-induced fluorescence, lesion area and visual inspection scores. Mean differences were calculated during the data extraction process. Ten studies including 559 patients were selected in the meta-analysis. Fluorides combined with CPP-ACP achieved the same efficacy for early caries lesions on smooth surfaces compared with fluorides monotherapy (mean difference: -13.90, 95% confidence interval: [-39.25, 11.46], P = 0.28), and the combination treatment showed significantly better efficacy than fluorides monotherapy for occlusal early caries lesions (mean difference: -21.02, 95% confidence interval: [-27.94, -14.10], P

Suggested Citation

  • Siying Tao & Yan Zhu & He Yuan & Sibei Tao & Yiming Cheng & Jiyao Li & Libang He, 2018. "Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0196660
    DOI: 10.1371/journal.pone.0196660
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    References listed on IDEAS

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    1. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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    Cited by:

    1. Andrea Poza-Pascual & Clara Serna-Muñoz & Amparo Pérez-Silva & Yolanda Martínez-Beneyto & Inmaculada Cabello & Antonio José Ortiz-Ruiz, 2021. "Effects of Fluoride and Calcium Phosphate-Based Varnishes in Children at High Risk of Tooth Decay: A Randomized Clinical Trial," IJERPH, MDPI, vol. 18(19), pages 1-15, September.
    2. Stefano Cianetti & Stefano Pagano & Michele Nardone & Guido Lombardo, 2020. "Model for Taking Care of Patients with Early Childhood Caries during the SARS-Cov-2 Pandemic," IJERPH, MDPI, vol. 17(11), pages 1-17, May.

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